August 13, 2008
Nanocarriers in PET
Hooker et al. from the University of California-Berkeley reported on April 25 ahead of print in Molecular Imaging and Biology on a modular synthetic strategy to append imaging agents to a viral capsid. The researchers labeled the inside surface of the hollow protein shell of bacteriophage MS2 (mtMS2) with ^sup 18^F- fluorobenzaldehyde through a multistep bioconjugation strategy. An aldehyde functional group was first attached to interior tyrosine residues through a diazonium coupling reaction. The aldehyde was further elaborated to an alkoxyamine functional group, which was then condensed with no carrier added ^sup 18^F-fluorobenzaldehyde. Biodistribution of the injected radioactive conjugates was evaluated in rats. ^sup 18^F-tabeled MS2 showed prolonged blood circulation time and a significantly altered excretion profile. Additional small molecule "cargo" installed in the capsids did not alter biodistribution. The authors concluded that these studies "provide further insight into the pharmacokinetic behavior of nanomaterials and serve as a platform for the future development of targeted imaging and therapeutic agents based on mtMS2." Molecular Imaging and BiologyCopyright Society of Nuclear Medicine Jul 2008
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