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Last updated on April 16, 2014 at 10:51 EDT

FEI’s Titan Krios TEM Selected By Leading Life Science Research Centers in Asia

November 3, 2008

FEI Company (Nasdaq: FEIC), a leading provider of high-resolution imaging and analysis systems, announced today that three of the top life sciences research centers in Asia–National University of Singapore, Tsinghua University (Beijing), and the Institute of Biophysics at the Chinese Academy of Sciences (Beijing)–have selected the Titan Krios(TM) transmission electron microscope (TEM) to support their research programs in structural molecular biology. Based on FEI’s renowned Titan(TM) TEM platform, the Titan Krios combines the power of the Titan electron optics, with a sophisticated cryogenic sample stage and sample handling robotics for a completely automated, high-throughput life sciences TEM solution. FEI’s Titan Krios enables researchers to create three-dimensional molecular-level images of biological material in its native hydrated state.

“Modern cryo-electron microscopes, such as the Titan Krios, are optimized for visualizing the molecular structures and interactions that we need to observe,” said Professor Wanzhong He of the National University of Singapore (NUS). “For instance, with cryo-electron tomography, we can look at intact cellular systems arrested at an instant in time. Not only can we see macromolecular structures down to a resolution of a couple of nanometers, we see them in the context of the neighboring structures and molecular entities with which they naturally interact. And, because we are capturing snapshots of individual molecular instances, we will be able to analyze the dynamic behavior of flexible proteins and follow the conformational changes that are at the heart of many biological structure-function relationships.” In addition to developing electron tomography (ET) as a technique, Prof. He’s research interests include using ET to trace endocytic trafficking events and to dissect the molecular mechanisms of genetic and infectious diseases. The Titan Krios will be located in the state-of-the-art NUS Cryo-EM facility, led by Prof. He. The new facility will be completed by summer 2009 and will be a key resource in the NUS Centre for BioImaging Sciences.

At Tsinghua University, Dr. Yigong Shi, vice director of the Institute of Biomedicine, will use the Titan Krios in research aimed at understanding the molecular mechanisms of tumorogenesis. At the Chinese Academy of Sciences, Professor Tao Xu’s research focuses on elucidating the molecular and cellular mechanisms underlying blood glucose regulation.

“The Titan Krios is a powerful platform for investigating cellular and molecular ultra-structure of proteins, viruses and liposomes,” said Matthew Harris, vice president and general manager of FEI’s Life Science Division. “It is specifically designed for the unique requirements of high-resolution and high-throughput life science imaging. The impressive capabilities of the Titan Krios open the gates to the investigational frontier of biological sciences, presenting opportunities for ground-breaking results and breakthrough discoveries.”

The Titan TEM platform delivers the fundamental mechanical, electronic and thermal stability required for ultimate performance in both life science and materials science applications. The Titan Krios, specifically designed for biological applications, is optimized for cryo-transmission electron microscopy, dual-axis cryo-electron tomography, and automated single particle analysis.

About FEI Company

FEI (Nasdaq: FEIC) is the world leader in pioneering technologies and applications that deliver imaging solutions for 3D characterization, analysis and modification/prototyping with resolutions down to the sub-Angstrom level. Our customers, working in advanced research and manufacturing, are supported by field-experienced applications specialists. They have open access to FEI’s prestigious global user network so they can succeed in accelerating nanoscale discovery and contribute to better living through new product commercialization. FEI’s NanoPorts in North America, Europe and Asia provide centers of technical excellence where our world-class community of customers and specialists collaborate on the ongoing development of new ideas and innovative solutions. FEI has sales and service operations in more than 50 countries around the world. More information can be found at: www.fei.com.

FEI Safe Harbor Statement

This news release contains forward-looking statements that include statements product orders for the Titan Krios and certain capabilities of that tool. Factors that could affect these forward-looking statements include but are not limited to our ability to manufacture, ship and deliver the tools as expected, final acceptance of the products and/or cancellation or delay of all or part of the order, and the ability of the tools to perform as expected. Please also refer to our Form 10-K, Forms 10-Q, Forms 8-K and other filings with the U.S. Securities and Exchange Commission for additional information on these factors and other factors that could cause actual results to differ materially from the forward-looking statements. FEI assumes no duty to update forward-looking statements.

The FEI logo, Titan and Titan Krios are trademarks of FEI Company.