June 11, 2009
Protein may predict cancer drug resistance
Dutch and U.S. medical researchers have discovered a protein profile that may predict whether a breast cancer patient will be resistant to tamoxifen therapy.
Tamoxifen is a widely used and effective drug designed to treat breast cancer. But the scientists said resistance to tamoxifen is problematic in recurrent disease that affects 25 percent to 35 percent of patients because therapy resistant metastatic tumor cells are a major cause of death.
While further work with additional samples will be needed, the researchers said the profile could be clinically useful, especially considering their approach used minute amounts of tissue samples, making it applicable at even the earliest tumor stages.
The research is detailed in the journal Molecular and Cellular Proteomics.