November 30, 2009
RNA On The Move
EMBL scientists are the first to visualize the mechanism responsible for oskar mRNA transport
In the fruit fly Drosophila, oskar mRNA, which is involved in defining the animal's body axes, is produced in the nuclei of nurse cells neighboring the oocyte, and must be transported to the oocyte and along its entire length before being translated into protein.
By combining immunofluorescence with electron microscopy imaging, the EMBL scientists were able to discriminate where different molecules critical for oskar mRNA transport are recruited, thus defining a hierarchy of RNA particle assembly. These findings not only increase our understanding of development, but could also shed light on processes underlying the function of dendrites and axons in neurons, and synaptic plasticity "“ which is implicated in learning and memory formation "“ as these also entail the transport and localized translation of RNA.
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