July 7, 2010
Protein Identified Which Helps Cancer Cells To Survive Stressful Conditions
Researchers at NUI Galway have made a discovery that could lead to the development of more effective treatments for a number of diseases. They have shown that a protein produced when cells are stressed interacts with a stress sensor allowing cells to survive conditions of intense stress. Understanding this interaction may help scientists interfere with cancer cells so the cells can no longer survive exposure to stressful conditions. These findings are published next week in the online, open access journal PLoS Biology.
Healthy cells are not usually under stress, but unhealthy cells, such as cancer cells, are often under considerable stress because they grow rapidly in places where they are not supposed to grow. When a cell is under these stressful conditions, the stress protein Hsp70 is activated to help the cell.
Professor Samali states: "Our results have identified a novel protein-protein interaction that helps cancer cells to survive stressful growth conditions. By interfering with this interaction we hope to develop a new class of anticancer drugs. This work was funded by Science Foundation Ireland and will have a significant impact on cancer research and drug design."
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