July 8, 2010
Gene Knockout Makes Female Mice Masculine
The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation with other female mice. Researchers writing in BioMed Central's open access journal BMC Genetics created the FucM mouse mutants in order to investigate the role of this enzyme in vivo.
Chankyu Park worked with a team of researchers from the Korea Advanced Institute of Science and Technology and intriguingly gained some insight into the neurological basis of sexual preference. He said, "The FucM knockout mice displayed drastically reduced sexual receptivity, although pregnancy after forced mating attempts by normal sexually experienced males showed that the animals were fertile. The FucM knock-out mice have reduced levels of alpha-fetoprotein, a protein thought to be involved in development of parts of the brain responsible for reproductive behavior".
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