September 21, 2010
Wake Up Your Brain
Orexin wakes up your brain by self-excitation mechanism
For advanced activities of our daily life (such as driving a car, or seeing a movie), to be awake is important. It has been known so far that neuropeptide in the brain called "Orexin"controls sleep and awakening besides appetite. Here, the research group led by Dr. Akihiro Yamanaka, National Institute for Physiological Sciences (NIPS), found that orexin-releasing neurons have the self-excitation mechanism that activate each other among them, and maintain awaking. From this result, the application to doze prevention or insomnia treatment can be expected. It is reported in the Journal of Neuroscience of the issue on September 22, 2010(the United States EST).
By this study, Dr. Yamanaka clarified the nerve mechanism which maintains awakening or raises awakening level. It can be considered that maintaining the orexin neuron activity highly by this mechanism is one of the insomnia mechanisms. He believes that this study results can be applied to the doze prevention and the treatment of the insomnia in the future.
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