October 25, 2010
Odor Coding In Mammals Is More Complex Than Previously Thought
A new study in the Journal of General Physiology (JGP) shows that the contribution of odorant receptors (ORs) to olfactory response in mammals is much more complex than previously thought, with important consequences for odorant encoding and information transfer about odorants to the brain. The study appears online on October 25 (www.jgp.org).
ORs, which provide a system for mammals to discriminate between many different odors, form a large, diverse group of G protein"“coupled receptors corresponding to around 1,000 functionally distinct receptors in rodents and 350 in humans. Besides providing odorant specificity to olfactory receptor neurons (ORNs) and contributing to ORN axon targeting, little is understood about the OR contribution to olfactory response.
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