Genetically engineered animals help in scientific research that may benefit children
Posted on: Wednesday, 21 September 2005, 16:11 CDT
Sept. 21, 2005 - The recent use of genetically modified mice and rats in combination with an animal model of obstructive nephropathy, a type of renal disease, has given researchers new insight in the development of kidney disease. This research is published in the September issue of Kidney International.
"Chronic kidney disease is difficult to study since it takes a fair amount of time to install," states Joost P. Schanstra, Ph.D. of the Instituit Louis Bugnard inFrance. "This animal model has the advantage of mimicking in a short time the different stages of chronic kidney disease. The combination of genetically engineered animals and this animal model has helped us to decide which molecules to study, or which might be interesting targets for drug development in human chronic kidney disease."
Obstructive nephropathy or obstructive uropathy, the kidney disease on which this animal model is based, is frequently found in children and is the first cause of end-stage renal disease (ESRD). According to the article, ESRD represents 16.1% of all pediatric transplantations in North America.
On the World Wide Web:
Related Articles
- Acologix AC-200 Demonstrates Positive Effect on Bone in Preclinical Model of Chronic Kidney Disease
- Xanthus' Symadex Reverses Disease in Preclinical Mouse Models of Multiple Sclerosis
- Stem Cells Useful in Animal Stroke Models
- Tissera Reports Achievement of Proof of Concept of the Curative Effect of Its Transplantation Technology in Large Animal Diabetic Model
- Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
- Tissera Reports Significant Milestone Achievement in Its Large Animal Diabetic Model Studies
- Tissera Reports Encouraging Preliminary Results of Its Large Animal Diabetic Model Experiments of Pancreatic Xenotransplantation
- Nitric Oxide Mediates the Blood-Pressure Lowering Effect of Garlic in the Rat Two-Kidney, One-Clip Model of Hypertension1,2
- Mayo Clinic Finds Kidney Disease Associated with "Benign" Prostate Obstruction
- Effects of Anticytokine Therapy in a Mouse Model of Chronic Asthma
 |
 |
User Comments (0)
RSS Feeds