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Researchers Uncover Viral Structure

Posted on: Wednesday, 4 January 2006, 21:00 CST

Researchers have solved the structure of a molecule that controls the ability of viruses of the paramyxovirus family to fuse with and infect cells.

The parainfluenza virus 5 is part of the paramyxoviruses family, which causes everything from pneumonia, croup and bronchiolitis to cold-like illness and is responsible for many hospitalizations and deaths each year.

Determining the structure of this molecule and its role in the viral fusion mechanism may aid the development of new drugs and vaccines.

The results the research. conducted at Northwestern University, will be published Jan. 5 by the journal Nature.

Although the basic concept of viral fusion has been understood for some time, the complete conformations of the structures of the before- and after-fusion forms of the F protein had eluded scientists until the recent work of the Northwestern team.


Source: United Press International

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