Strategy Developed to Study Cancer
Posted on: Tuesday, 7 March 2006, 21:00 CST
Johns Hopkins University researchers say they have easily jumpstarted the activity of a well-known cancer protein in live cells with a small molecule.
The scientists say their achievement leads to a strategy that pinpoints key players in the cancer process and can be used to determine new therapeutic targets.
What's more, the study identifies a simple method to further understand the complex mechanisms that underlie cancer, and other diseases, and may provide an easy model to screen for new cancer drugs, the university said in a news release.
Our study reveals a new way to study proteins in live cells, in this case, a tyrosine kinase implicated in causing cancer, said the study's lead author, Philip Cole, director of the department of pharmacology and molecular sciences at The Johns Hopkins University School of Medicine.
This approach helped identify potentially important therapeutic targets and in the future may provide a method to easily screen cancer treatments, said Cole.
The research is detailed in the March 3 issue of the journal Science.
Source: United Press International
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