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Licha K.: Molecular Imaging. An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy

Posted on: Friday, 17 March 2006, 06:00 CST

By Lucignani, G

Bogdanov, A. A., Licha K.: Molecular Imaging. An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy. - A 258- page volume with 79 figures - Berlin: Springer. 2004.

Molecular medicine is a new strategy in medical science, and its principal goals are 2-fold. The first is to gain an in-depth understanding at the molecular level of the causes of diseases. The second is to exploit such knowledge to anticipate - before even the onset of symptoms - both diagnosis and treatment. This substantial change in the way we approach diseases is a historical turning point, and requires a new vision, new methods and innovative instruments, with which to diagnose and treat diseases from the molecular standpoint.

This book summarizes the discussion over the rapidly evolving technologies and numerous applications in the area of molecular imaging for preclinical research, and the opportunities to use molecular imaging for developing new strategies for patient care. The book covers the different molecular imaging methods, and illustrates the advances in molecular biology, that make possible and stimulate the development of molecular imaging methods. The advances of molecular imaging have been made possible by the work of a relatively small group of scientists, many of whom report their seminal work and vision in this book.

In 12 chapters, written by world experts, the book summarizes the following: Oligonucleotides as radiopharmaceuticals. Imaging Protein- Protein interactions in whole cells and living animals. Radiolabeled peptides in nuclear oncology: influence of peptide structure and labeling strategy in pharmacology, Inretargeted immunotherapy, PET/ CT: combining function and morphology. High relaxivity contrast agent for MRI and molecular imaging. Luminescence lanthanide complexes as sensor and imaging probes. Magnetic resonance signal amplification probes, Imaging of proteases for tumor detection and differentiation. Molecular imaging with targeted ultrasound contrast microbubbles, Noninvasive real-Time in vivo bioluminescent Imaging of gene expression and of tumor progression and metastasis. Targeted optical imaging and photodynamic therapy.

The book is an essential tool for biotechnologists, pharmacologists, racliochemists. radiopharmacists. molecular biologists and all those who work in the field of preclinical research applied to molecular imaging, with a wide variety of detector systems (MRI, SPET, PET. Optical), and in radionuclide therapy.

G. L.

Copyright Edizioni Minerva Medica Dec 2005

Source: Quarterly Journal of Nuclear Medicine, The

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