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Gene Defect Linked to Premature Aging

Posted on: Saturday, 1 May 2004, 06:00 CDT

Finding may also lead to new way to treat cancer, researchers say

HealthDayNews -- A gene defect linked to premature aging that may offer a new way to treat cancer has been identified by researchers at Johns Hopkins Kimmel Cancer Center.

Using genetically engineered mice, the scientists found that when the gene PASG is altered, it causes cells and animals to age prematurely and die. This gene may provide a new target for therapies that force cancer cells to an early death.

The study appears in the May 1 issue of Genes and Development.

Mice with the mutated PASG gene suffered numerous problems such as low birth weight, graying and loss of hair, reduced fat, skeletal abnormalities and early death.

"To keep body tissues working correctly, the PASG gene appears to help cells regenerate, mature and prevent early aging. Each cell is programmed with a set number of replications before it dies. With a mutated PASG gene, the cell may replicate only a fraction of the time, and then it dies prematurely," study director Dr. Robert Arceci, King Fahd Professor and director of pediatric oncology, said in a prepared statement.

If PASG's activity could be blocked in cancer cells, it may be possible to make them age faster and die earlier, he said.

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On the Net:

American Academy of Orthopaedic Surgeons

Johns Hopkins Kimmel Cancer Center

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Copyright © 2004 HealthDay. All rights reserved. The information contained above is intended for general reference purposes only. It is not a substitute for professional medical advice or a medical exam. Always seek the advice of your physician or other qualified health professional before starting any new treatment.

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