• E-mail
• Print
• Comment
• Font Size
• Digg
• del.icio.us
• Discuss article

S 2-33: Analysis of the Regulatory Network of APP, Amyloid Beta Protein Precursor, With the Signal Transduction Database TRANSPATH Professional

Posted on: Tuesday, 8 June 2004, 06:00 CDT

TRANSPATH is a signal transduction database that collects data about reactions of signaling molecules. We try to cover complete pathways from extracellular ligands down to transcriptional control of specific genes. TRANSPATH describes molecules and reactions at different detail levels: The most detailed 'experimental evidence' level presents reactions in a mechanistic way, following strictly the original data of the evaluated primary literature. The 'pathway level' of mechanistic reactions represents the knowledge about mechanistic reactions and their sequences in a nonredundant way by summarizing all the underlying experimental evidence. The highest level of abstraction, the 'semantic projection', consists of sequential chains of the main signaling molecules transferring a signal along a pathway. Moreover, TRANSPATH is intensely cross- linked with many other databases including TRANSFAC.

We demonstrate the properties of TRANSPATH Professional in particular the visualization tool PathwayBuilder1(TM)' and the ArrayAnalyzer1(TM)' for the analysis of gene expression data with the APP (Amyloid beta Precursor Protein) network as an example. Alzheimer's disease has been found to be caused by defects in APR TRANSPATH can be used to depict the regulatory network around this protein, that may help to explain the processes leading to the development of this disease.

Susanne Pistor* (spi@biobase.de), Claudia Choi , Mathias Krull , Nico Voss , Anatolij Potapov, Edgar Wingender #,

* corresponding author

BIOBASE GmbH, Halchtersche Strosse 33, D-38304 Wolfenbuttel;

# Dept. ofBioinformatics, University of Goettingen, Goldschmidtstr.1, D-37077 Goettingen

Copyright Urban & Fischer Verlag Mar 2004

More News in this Category