Blue Heron Biotechnology, Inc. Awarded Grant for Universal Restriction Enzyme and Large DNA Fragment Assembly
Posted on: Thursday, 9 September 2004, 06:00 CDT
Blue Heron Biotechnology, Inc. announced today that it has been awarded a Phase I Small Business Innovative Research (SBIR) grant from the National Institute of General Medical Science (NIGMS) and the National Human Genome Research Institute (NHGRI). The $137,910 grant will fund research to develop a "universal" restriction enzyme system. The goal of the grant is to develop a uniform method for assembling large DNA molecules by ligation of sticky-ended fragments, regardless of the sequence, the fragment length, or the presence of restriction sites. If successful, it will enable the use of restriction digestion to release any cloned fragment and allow complete control of the sticky ends on these fragments. This "universal cutter" will support the reliable assembly of DNA fragments of 100,000 base pairs or larger and allow Blue Heron Bio to extend its GeneMaker(R) gene synthesis service to include large genomic DNA fragments and bacterial genomes. Moreover, the technology will increase GeneMaker's efficiency for the shorter genes, e.g., 1,000 to 5,000 base pairs, which most researchers study.
Dr. John Mulligan, President and CEO, stated, "The SBIR program has allowed Blue Heron Bio to develop a set of exciting new technologies that could revolutionize the way scientists approach biological problems. The universal cutter technology that is the focus of this grant will have broad applications in molecular biology while also pushing our gene synthesis platform into the realm of very large genes and whole genome synthesis. We are very excited about the potential results from this new grant and the progress on our existing SBIR grants."
About Blue Heron Biotechnology
Blue Heron Biotechnology, Inc., the leading provider of gene synthesis services, was founded in 1999 to accelerate discovery research by industrializing the manufacture of custom reagents. Blue Heron Bio's proprietary GeneMaker(R) synthesizes any gene, regardless of sequence or size with 100% accuracy guaranteed. Today, hundreds of researchers from pharmaceutical and biotechnology companies as well as academic and government laboratories buy synthetic genes from Blue Heron Bio.
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