A New Proteomic Database for the Plant Cell Wall
Posted on: Saturday, 30 October 2004, 03:00 CDT
Despite the importance of cell walls to the biology of plants, not much is known about the biosynthesis and function of their major macromolecular components. Biochemical approaches have only been successful thus far in characterizing a few of the hundred of enzymes that are probably involved in cell wall function. Moreover, comparative molecular genetic studies have provided little insight because the walls of other organism groups, such as bacteria and yeast, are fundamentally different in composition, structure, and function from those of plants. Recent advances in genomics make it possible to quickly identify large numbers of genes as being putatively involved in particular plant cell processes. With these new resources for identifying candidate genes encoding biosynthetic enzymes and regulatory proteins in cell walls comes the challenge of extracting the critical information from complex data sets to guide the functional analysis of these genes and the proteins they encode. To fill this need, Girke et al. (pp. 3003-3008) have created and are maintaining Cell Wall Navigator (CWN), a web-based database that integrates cell wallrelated protein families and allows easy comparison among sequences derived from fully sequenced plant genomes plus the known protein sequences from other species. The CWN database has numerous visualization and interactive mining tools and an adaptable design for organizing complex protein families across many organisms to cover the complete space of known sequences. CWN's flexible architecture and automated update and analysis features allow for the rapid integration of new families and up-to-the- minute information on cell all proteins.
www.plantphysiol.org/cgi/doi/ 10.1104/pp.l04.900123 Copyright American Society of Plant Physiologists Oct 2004
Source: Plant Physiology
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