March 26, 2013
Patients Who Have Difficulty Swallowing Could Soon Be Tested More Effectively
University of Pittsburgh
From a diagnosis success rate of less than 50 percent to 90 percentThose suffering from swallowing difficulties, especially stroke patients, could be evaluated more efficiently and noninvasively thanks to research under way at the University of Pittsburgh and the University of Toronto.
Ervin Sejdic, assistant professor of electrical and computer engineering in Pitt's Swanson School of Engineering, is developing a small sensor that's externally placed on the neck near the thyroid and records how a person swallows. The primary author of a study on the sensor published online in IEEE Transactions of Biomedical Engineering, Sejdic uses simulation modeling to posit a mathematical solution to the low diagnostic success rate of current swallowing tests.
"We've seen a lot of patients, especially those suffering from strokes, die from difficulty swallowing," said Sejdic. "This disorder, known medically as dysphagia, can have dire consequences like malnutrition, dehydration, pneumonia, and even death. Unfortunately, current methods are often cumbersome and not as effective as they need to be."
In their paper, Sejdic and his University of Toronto collaborators suggest a mathematical algorithm that works electronically "behind the scenes" to improve the images captured by his neck sensor, which is the size of a quarter and affixed using double-sided tape. He and his team tested the model sensor on 40 dysphagic patients, who were instructed to take several sips of liquid in a head-neutral position. The result was a 90 percent success rate in diagnosing dysphagia.
Today's dysphagia evaluations make use of videofluoroscopy exams–motion x-rays prescribed by speech-language pathologists–that take snapshots of the throat, said Sejdic. These exams are effective at tracking whether food is going into one's airway instead of the stomach (aspiration); which parts of the mouth and throat may not be working well; and whether certain positions or strategies help a person swallow better.
"Unfortunately, people eat or drink something 10 to 20 times a day," said Sejdic. "And you can't put a person in front of an x-ray that many times, nor does every hospital have the capability to do so."
For stroke patients rushed into the hospital, an even more basic exam is administered. This includes simple water tests in which patients drink a glass of water and are evaluated on whether they cough or have "wet voice" (a condition where it sounds like patients are producing words through moisture). However, those tests show an even lower level of efficacy.
"These simple tests have a success rate below 50 percent," said Sejdic. "You're better off flipping a coin."
Sejdic and his colleagues have been working on their model sensor for almost three years, and negotiations are under way for a clinical trial in the United States and Canada. While the researchers' neck sensor could help all patients with dysphagia, they are specifically targeting stroke sufferers, as this occurs in 37 to 78 percent of those patients.