Gastric Chief Cell

The Gastric Chief Cell (peptic cell or gastric zymogenic cell) is a cell found in the stomach that releases pepsinogen, gastric lipase and Chymosin (an enzyme that clots milk). Pepsinogen is only released when the cell is stimulated by a number of factors, including cholinergic activity and increased acidity in the stomach.

The gastric chief cell works in conjunction with the parietal cell, which releases gastric acid, converting pepsinogen into pepsin.

The term “chief cell” is often used without the word “gastric” to name this type of cell. However, this term is also associated with other cell types in the human body, including the parathyroid chief cell. Chief cells are also known as peptic cells.

Image Caption: Histopathologic image of fundic gland polyp obtained by endoscopic gastric biopsy. Photographed by CCD camera through Olympus microscope, then modified by auto-contrast function in Adobe software. Credit: Wikipedia(CC BY-SA 3.0)