The rabies virus is neurotropic virus, transmissible through the saliva of animals, that causes fatal disease in human and animals. Rabies is the type species of the Lyssavirus genus of Rhabdovirdae family. They are enveloped and single stranded RNA genome with negative-sense.
All replication takes place in the cytoplasm. The virus has a bullet-like shape. Rabies enters the host cells through the endosomal transport pathway after receptor binding. After entry transcription of the viral genome by the P-L polymerase is the next step in order to make new viral protein. The virus travels quickly from the wound of entry and moves along the neural pathways to the central nervous system. From there the virus spreads to other organs and end up in high concentration in the salivary glands. Fatality can occur from two to five days after initial infection.