Discovery launched from Kennedy Space Center on November 8, 1984 at 7:15 AM EST and landed at Kennedy on November 16 at 6:59 AM EST. The shuttle orbited 127 times at an altitude of 185 nautical miles at an angle of 28.5 degrees and travelled 3.3 million miles. The mission lasted 7 days, 23 hours, 44 minutes, and 56 seconds.

The Canadian communications satellite TELESAT-H (ANIK), attached to Payload Assist Module-D (PAM-D) was deployed into geosynchronous orbit on flight day two. On the third day, the defense communications satellite SYNCOM IV-I (also known as LEASAT-1) was deployed. Allen and Gardner, wearing jet-propelled manned maneuvering units, retrieved two malfunctioning satellites: PALAPA-B2 and WESTAR-VI, both of these satellites were deployed on Mission 41-B. Fisher operated the remote manipulator system, grappling satellites and depositing them in the payload bay. Middeck payloads for this mission were: Diffusive Mixing of Organic Solutions (DMOS), and Radiation Monitoring Equipment (RME).

Discovery was crewed by Commander Frederick P. Hauck, Pilot David M. Walker, Mission Specialists Anna L. Fisher, Dale A. Gardner, and Joseph P. Allen.