Viruses have numerous tricks for dodging the immune system. In the September 7, 2009 issue of the Journal of Cell Biology, Stagg et al. reveal a key detail in one of these stratagems, identifying a protein that enables cyto¬megalovirus to shut down an antiviral defense (online August 31).

Type 1 diabetes is thought to result from the destruction of β-cells by autoantigen-speciflc T-cells. Observations in the NOD mouse model suggest that CD8^sup +^ cytotoxic T-cells play an essential role in both the initial triggering of insulitis and its destructive phase.

Little is known about the role of CD1d-restricted T cells in antiviral immune responses. Here we show that the lytic replication cycle of the Kaposi sarcoma-associated herpesvirus (KSHV) promotes downregulation of cell-surface CD1d.

There is increasing evidence that the immune response can be inhibited by several T cell subsets, including NK T cells, CD25^sup +^CD4^sup +^ T cells, and a subpopulation of CD8^sup +^ T cells.

Saturday, April 24, 2004 NEW STRATEGIES FOR ANTIGEN DELIVERY The development of vaccines to prevent diseases or to treat infections or cancer is considered a high priority.