--Children's Hospital of Philadelphia Scientist Leads Largest-Ever Genome-Wide Study of this Pediatric Condition-- PHILADELPHIA, April 9, 2012 /PRNewswire-USNewswire/ --

--Children's Hospital of Philadelphia Research Suggests that Interventions at the Glutamate Transmission Level Might Treat Disorder--

Children's Hospital of Philadelphia researchers add to gene inventory of a complex disorder.

-Children's Hospital of Philadelphia Researcher Shows Proof-of-Principle for New Tool Called VAAST, Using DNA from Handful of Subjects in Two Families- PHILADELPHIA, June 23, 2011 /PRNewswire-USNewswire/ -- Harnessing the new generation of rapid, highly accurate gene-sequencing techniques, a research team has identified the disease-causing mutation in a newly characterized rare genetic disease, by analyzing DNA from just a few individuals.

By analyzing the genomes of patients with schizophrenia, genetics researchers have discovered numerous copy number variations—deletions or duplications of DNA sequences—that increase the risk of developing schizophrenia.