By Isaacs, Jeremy D; Ingram, Rebecca J; Collinge, John; Altmann, Daniel M; Jackson, Graham S Abstract T cell immune responses to central nervous system-derived and other self-antigens are commonly described in both healthy and autoimmune individuals.

By Khoury, Thaer; Gonzalez-Fernandez, Federico; Munschauer, Fredrick E III; Ostrow, Peter Pathologic Diagnosis: Vogt-Koyanagi-Harada Syndrome (Uveomeningoencephalitic Syndrome) Abstract The clinicopathologic findings of this patient were typical for Vogt-Koyanagi-Harada syndrome.

Type 1 diabetes is thought to result from the destruction of β-cells by autoantigen-speciflc T-cells. Observations in the NOD mouse model suggest that CD8^sup +^ cytotoxic T-cells play an essential role in both the initial triggering of insulitis and its destructive phase.

Abstract The nonclassical MHC class I molecule HLA-E is the only known ligand for CD94/NKG2A and CD94/NKG2C expressed on NK and CD8^sup +^ αβ and γδ T cells. HLA-E may transmit either activating signals via CD94/NKG2C or inhibitory signals mediated by CD94/NKG2A.

Prevailing models of sarcoidosis pathogenesis involve the activation of alveolar macrophages, aggregation of CD4^sup +^ T lymphocytes, and their accumulation in epithelioid cell granulomas. Increasing evidence suggests that each of these steps is modified by the host genetic constitution.