Changing how a person perceives and thinks about others was the most effective intervention for loneliness, a sweeping analysis of previous research has determined.

Chronic feelings of loneliness take a toll on blood pressure over time, causing a marked increase after four years, according to a new study at the University of Chicago.

People who feel lonely spread that feeling to others.

Social isolation affects how people behave, as well as how their brains operate, a University of Chicago study found. John Cacioppo said the study used functional Magnetic Resonance scans to study the connections between perceived social isolation -- loneliness -- and activity in the brain.

Many try to identify with animals, gadgets, spiritual beliefs