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Latest Acetylcholine Stories

2010-05-04 08:56:00

GENEVA, SWITZERLAND, May 4 /PRNewswire-FirstCall/ - Anavex Life Sciences Corp. ("ANAVEX") (OTCBB: AVXL) is pleased to report promising results from animal studies with ANAVEX 2-73, the company's lead compound for the treatment and modification of Alzheimer's disease. ANAVEX 2-73 is the first of a new class of drugs that target mitochondrial dysfunction thought to be caused by oxidative stress to modify Alzheimer's disease. This novel mechanism acts primarily via sigma receptors and is not a...

2010-03-17 06:00:00

CARMIEL, Israel, March 17 /PRNewswire-FirstCall/ -- Protalix BioTherapeutics, Inc. (NYSE-Amex: PLX) announced today that it has initiated a phase I clinical trial of PRX-105, the Company's plant cell expressed pegylated recombinant human acetylcholinesterase product candidate in development for biodefense indications. The trial is designed to study the safety of PRX-105 by administering a bolus intravenous injection of PRX-105 in healthy volunteers. The U.S. Food and Drug Administration...

2010-02-01 16:08:34

Scientists at the Robarts Research Institute at The University of Western Ontario, working in collaboration with researchers in Brazil, have used a unique genetically-modified mouse line to reveal a previously unidentified mechanism contributing to heart failure. The study, led by Marco Prado, Robert Gros and Vania Prado of London, Canada and Silvia Guatimosim of Brazil, shows how the decreased release of the neurotransmitter acetylcholine, a chemical messenger which slows cardiac activity,...

2010-01-19 12:24:48

Researchers from the University of British Columbia and Harvard University have co-developed a system that captures on video and barcodes the behavioral responses of zebrafish to chemical compounds on a large scale. The approach could dramatically speed up the discovery of new psychiatric drugs. The discovery in the 1950s of drugs that act in the nervous system has been important both for the understanding of neurobiology and the treatment of neurological diseases. Since then, very few new...

2010-01-12 18:46:54

A fast-acting compound that appears to improve cognitive function impairments in mice similar to those found in patients with progressive Alzheimer's disease has been identified by scientists at Wake Forest University School of Medicine and the Vanderbilt University Medical Center Program in Drug Discovery. Researchers hope to one day replicate the result in humans. The compound "“ benzylquinolone carboxylic acid (BQCA) "“ has also been shown in previous rodent studies to lessen...

2010-01-12 10:46:00

WATERTOWN, Mass., Jan. 12 /PRNewswire-USNewswire/ -- Research shows that what's good for the heart and cardiovascular system is also good for the brain, according to the Alzheimer's Association. The "Run for the Memory" team has been braving cold temperatures to get in shape for the Boston Marathon(R) on April 19, and team organizers are encouraging others to keep in shape as well. (Logo: http://www.newscom.com/cgi-bin/prnh/20100112/DC36305LOGO) "There's no question that keeping...

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2010-01-10 15:36:53

Researchers at the Indiana University and Stanford University schools of medicine have determined how a "chemical chaperone" does its job in the body, which could lead to a new class of drugs to help reduce the muscle damage caused by heart attacks. Such drugs would work by restoring the activity of a mutated enzyme, rather than taking the more common approach of blocking the actions of a disease-related protein. The team, led by Thomas Hurley, Ph.D., associate chair and professor of...

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2009-12-14 07:28:25

Scientists have resolved a question about how a popular class of drugs used to treat schizophrenia works using biosensors that reveal previously hidden components of chemical communication in the brain. Although delusions and hallucinations characterize the illness, people with schizophrenia also struggle to sustain attention or recall information in a particular order, difficulties that interfere with their ability to hold a job or function well, said Lee Schroeder, a student in the medical...

2009-11-13 16:07:00

HOUSTON, Nov. 13 /PRNewswire/ -- Plagued by a growing weakness that left her unable to walk, talk and even take a normal breath, 11-year-old Iraqi Aram Ali was a shell of the bright little girl she used to be. No one could figure out what was wrong. Not the 13 doctors her distraught parents saw in Syria, not the specialists in Britain who had reviewed her chart, not the additional physicians she had seen in Iraq, the war-torn country the family had fled in a desperate effort to find the...

2009-10-02 10:41:57

New study finds that older people hospitalized for bradycardia are more likely to be taking cholinesterase-inhibiting drugs such as donepezil People taking one of several drugs commonly prescribed to treat Alzheimer's disease are more likely to be hospitalized for a potentially serious condition called bradycardia than patients not taking these medications. Researchers from St. Michael's Hospital and Ontario's Institute for Clinical Evaluative Sciences (ICES) analyzed data from 1.4 million...