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Latest Acetylcholine Stories

2009-07-15 08:00:00

VIENNA, July 15 /PRNewswire/ -- EnVivo Pharmaceuticals today announced the successful completion of a phase Ib/IIa trial in Alzheimer's disease patients with its nicotinic alpha-7 agonist EVP-6124. Subjects receiving EVP-6124 experienced improvement in cognition and EVP-6124 showed good tolerability and safety. The announcement came at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD) in Vienna, Austria where EnVivo presented its findings. EVP-6124...

2009-07-07 08:00:00

WATERTOWN, Mass., July 7 /PRNewswire/ -- WHAT: EnVivo Pharmaceuticals to share results from its Ib/IIa trial in Alzheimer's disease patients with its nicotinic alpha-7 agonist EVP-6124. WHEN: Wednesday, July 15, 2009. WHERE: Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD) in Vienna, Austria. WHO: Dana Hilt, MD, senior vice president,...

2009-06-30 08:48:04

A study published this week in the open access journal PLoS Medicine finds no evidence to suggest that a controversial antidote recommended by the World Health Organisation (WHO) to treat patients poisoned with highly toxic insecticides improves their chance of survival. The results may even add weight to existing concerns about pralidoxime, the treatment recommended by the WHO, by suggesting that it could be harmful in patients who have deliberately poisoned themselves with...

2009-06-02 13:45:59

Drugs -- many over-the-counter -- for allergies, hypertension or asthma can cause cognition problems in the elderly, U.S. researchers found. Study author Dr. Malaz Boustani of the Indiana University School of Medicine and Regenstrief Institute and colleagues conducted an analysis of 27 peer-reviewed studies of the relationship of the anti-cholinergic effect in some drugs -- a toxic reaction -- and brain function. Many medications used for several common disease states have anti-cholinergic...

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2009-04-24 09:39:39

The calming neurological effects of nicotine have been demonstrated in a group of non-smokers during anger provocation. Researchers writing in BioMed Central's open access journal Behavioral and Brain Functions suggest that nicotine may alter the activity of brain areas that are involved in the inhibition of negative emotions such as anger. Jean Gehricke led a team of researchers from the University of California who studied the effect of nicotine patches on the subjects' tendency to...

2009-04-09 07:45:00

NEW YORK, April 9 /PRNewswire/ -- According to Drs. Timothy Salthouse and Eric R. Braverman, the effects of the brain's cognitive abilities become less effective as early as our mid-twenties. A recent study by Dr. Timothy Salthouse, a University of Virginia professor of psychology and the study's lead investigator, shows that people lose their full capacity to make rapid comparisons, remember unrelated information, and detect relationships. Dr. Eric R. Braverman, author of the New York...

2009-04-06 16:17:59

Nicotine isn't just addictive, it may also interfere with dozens of cellular interactions in the body, U.S. researchers suggest. Brown University researchers say the data could help scientists develop better treatments for various diseases. It opens several new lines of investigation, lead author Edward Hawrot says in a statement. Hawrot and a team that included graduate students William Brucker and Joao Paulo looked specifically at the alpha-7 nicotinic acetylcholine receptor in mouse brain...

2009-04-01 08:00:00

WATERTOWN, Mass., April 1, /PRNewswire/ -- EnVivo Pharmaceuticals today announced an agreement with Mitsubishi Tanabe Pharma Corporation (MTPC) for the development and commercialization of its lead product candidate, EVP-6124, in Japan and several other Asian countries. EVP-6124 is EnVivo's novel alpha-7 nicotinic acetylcholine receptor agonist currently in development for cognition enhancement in patients with Alzheimer's disease and Schizophrenia. EnVivo recently reported positive results...

2009-03-24 09:18:54

-A tiny genetic mutation is the key to understanding why nicotine--which binds to brain receptors with such addictive potency--is virtually powerless in muscle cells that are studded with the same type of receptor. That's according to California Institute of Technology (Caltech) researchers, who report their findings in the March 26 issue of the journal Nature.By all rights, nicotine ought to paralyze or even kill us, explains Dennis Dougherty, the George Grant Hoag Professor of Chemistry at...

2009-02-10 09:15:24

A research team led by Northwestern University reports that insulin may slow or prevent the damage and memory loss caused by toxic proteins affiliated with Alzheimer's disease. The study shows how insulin shields memory-orming synapses from harm. The researchers looked at neurons taken from one of the brain's crucial memory centers, the hippocampus. They treated cells with insulin and rosiglitazone, a drug commonly used to treat type 2 diabetes. The cells are susceptible to damage caused by...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'