Quantcast
Last updated on April 24, 2014 at 13:57 EDT

Latest Actin Stories

2009-03-19 10:46:15

HZI researchers identify molecular signal pathway in diarrhea illnesses The bacterium Escherichia coli is part of the healthy human intestinal flora. However, E. coli also has pathogenic relatives that trigger diarrhea illnesses: enterohemorrhagic E.coli bacteria. During the course of an infection they infest the intestinal mucosa, causing injury in the process, in contrast to benign bacteria. The EHECs adhere to the surface of the mucosal cells and alter them internally: a part of the...

2009-03-16 13:18:30

U.S. medical scientists say they have discovered a new method to prevent bacterial infections by using the body's own enzymes. Dr Quinn Parks and colleagues at Denver's National Jewish Health Hospital said they used enzymes against products of the body's own defense cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm that enables the bacteria to avoid both the body's immune mechanisms and antibiotics. When the body's defense cells, called neutrophils, attack P....

2009-01-14 06:18:27

A protein that was first identified for playing a key role in regulating normal heart rhythms also appears to be significant in helping muscle cells survive the forces of muscle contraction. The clue was a laboratory mouse that seemed to have a form of muscular dystrophy. A group of proteins called ankyrins, or anchor proteins, were first discovered in human red blood cells by Vann Bennett, M.D. a Howard Hughes Medical Institute investigator and James B. Duke Professor of Cell Biology,...

d1c0bd59c69804e522f308cc1a39487e1
2008-12-09 10:19:28

Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. Their work describing the mechanism of the contractile ring "“ a structure that pinches the mother cell into two daughter cells "“ has been published in the December 5 issue of the journal Science. The division of one cell into two is accomplished...

c69d551e61ab3d5c23dceb68bd67f44a1
2008-11-25 11:40:00

Flip open any biology textbook and you're bound to see a complicated diagram of the inner workings of a cell, with its internal scaffolding, the  cytoskeleton, and how it maintains a cell's shape. Yet the fundamental question remains, which came first: the shape, or the skeleton?Now a research team led by Phong Tran, PhD, Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine, has the answer: Both.The findings, published online this...

2008-06-27 06:02:23

By Dinh, Anh-Tuan Pangarkar, Chinmay; Mitragotri, Samir Unlike macroscopic problems in mass, energy and momentum transfer, which are described by continuum equations, the movements and interactions of the nanoscale entities within a cell constitute a transport phenomenon known as discrete nanoscale transport (DNT). Imagine yourself on an alien spaceship, watching the daily goings- on of a large city through a telescope. You would see (among other things) complex transportation systems...

1a9c57a22b0bd3b6780bcc2d17882fe01
2008-04-10 14:20:00

Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called leiomodin (Lmod) promotes the assembly of an important heart muscle protein called actin. What's more, Lmod directs the assembly of actin to form the pumping unit of the heart. The findings appear in this week's issue of Science."Very little was known about Lmod when we began this study," says lead author Roberto Dominguez, PhD, Associate Professor of Physiology. "It appeared that this...

2005-11-23 13:28:28

Researchers at the Albert Einstein College of Medicine and the German Cancer Research Institute have shown how protein synthesis is targeted to certain regions of a cell--a process crucial for the cellular motility that governs nerve growth, wound healing and cancer metastasis. Their study appears in the November 24 issue of the journal Nature. Led by Drs. Robert Singer and Dr Stefan Huettelmaier, the research team focused on migrating fibroblast cells important in wound healing. To move...

2005-10-14 14:10:29

Biological cells are mechanically stable because they contain actin filaments and microtubules that form networks and bundles. These filament architectures are determined and controlled by crosslinking proteins, which have two sticky ends that bind to different filaments. In order to understand the underlying forces and to optimise the mechanical properties of these architectures, one must study biomimetic model systems that are solely composed of filaments and crosslinking proteins. One...

2005-07-13 14:20:00

Microtubules need a helping hand to find chromosomes in dividing egg cells, scientists have discovered. Although it was generally accepted that microtubules act alone as the cellular ropes to pull chromosomes into place, a new study by researchers at the European Molecular Biology Laboratory (EMBL) shows that this is not the case. They found that in large cells such as animal eggs, something else is needed to move the chromosomes into the correct location - fibres of the cytoskeletal molecule...