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Latest Activating transcription factor 2 Stories

2012-02-03 09:16:18

Study identifies protein kinase C-epsilon as a molecular switch that determines tumor-promoting or -suppressing activity in skin cells The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma–the deadliest form of skin cancer–at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the molecular mechanisms...

2010-12-24 12:59:15

Melanoma is one of the least common types of skin cancer, but it is also the most deadly. Melanocytes (pigment-producing skin cells) lose the genetic regulatory mechanisms that normally limit their number, allowing them to divide and proliferate out of control. One such regulator, called MITF, controls an array of genes that influence melanocyte development, function and survival. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and their collaborators recently used...