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Latest Adenoviridae Stories

2009-07-05 17:00:00

EMERYVILLE, Calif. and HUENENBERG, Switzerland, July 5 /PRNewswire-FirstCall/ -- Alcon, Inc. (NYSE: ACL) and its partner, NovaBay Pharmaceuticals, Inc. (NYSE-AMEX: NBY), announced today that Alcon has begun treating patients in a Phase 2 clinical trial of NovaBay's patented lead Aganocide(R) compound, NVC-422, for viral conjunctivitis, a type of "pink eye". Conjunctivitis is a pervasive and painful condition that affects both adults and children, leading to more than four million doctor and...

2009-06-23 11:14:06

Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry therefore seems a promising option to improve adenoviral entry into pancreatic cancer cells and to enhance the...

2009-06-21 06:33:55

Specially designed virus-derived vectors "“ engineered not to cause disease "“ can take therapeutic genes to the malfunctioning peripheral neurons outside the spinal cord and brain, alleviating the pain and other dysfunction that can result from a chronic disease or drug treatment, said researchers from Baylor College of Medicine and the University of Glasgow in a report in the current issue of the Journal of Clinical Investigation. "These disorders that affect the dorsal root...

2009-06-19 09:36:03

Sensory neuronopathies, nerve dysfunction that affects nerves outside the brain and spinal chord, are extremely painful. They include shingles and can be caused by anti-cancer drugs such as cisplatin. In many sensory neuronopathies, the nerves that are dysfunctional are those in a region of the body known as the dorsal root ganglion (DRG), and these conditions are particularly difficult to treat. Dr. Lawrence Chan and colleagues at Baylor College of Medicine, Houston, TX, have developed an...

2009-06-15 16:44:58

Medical conditions that affect sensory nerves outside the brain and spinal cord are known as sensory neuronopathies. These conditions, which are extremely painful, include shingles and can be caused by anticancer drugs such as cisplatin. In many sensory neuronopathies, the nerves that are dysfunctional are those in a region of the body known as the dorsal root ganglion (DRG), and these conditions are particularly difficult to treat. However, Lawrence Chan and colleagues, at Baylor College of...

2009-05-22 13:54:24

Human trials of a virus that kills cancer cells in mice without harming healthy cells is at least two years away, British researchers said. An adenovirus that causes chest infections was modified to deliver genetic therapy to liver tumors in mice without poisoning healthy tissue, said Leonard Seymour, a cancer researcher at the University of Oxford. The approach we developed is easy to use and flexible, Seymour said. It may help in the development of future therapeutic viruses that are...

2009-05-22 10:12:09

Scientists have determined how to produce replication-competent viruses with key toxicities removed, providing a new platform for development of improved cancer treatments and better vaccines for a broad range of viral diseases.Cellular microRNA molecules regulate the stability of mRNA in different cell types, and this newly-understood mechanism provides the possibility to engineer viruses for cell-specific inactivation. Cancer Research UK scientists at the University of Oxford, United...

2009-05-05 12:00:48

 Many proteins do not function by themselves as stand-alone units. Instead, multiple proteins associate to form larger structures called protein complexes. The May issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc5_09.dtl) features a set of methods that can be used to analyze protein complexes. An additional featured article details the generation of viral vectors for gene transfer."Systematic Monitoring of Protein Complex Composition and Abundance by Blue-Native...

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2009-04-08 09:05:00

Scientists at the University of Michigan have developed a method of gene delivery that appears safe for regenerating tooth-supporting gum tissue"”a discovery that assuages one of the biggest safety concerns surrounding gene therapy research and tissue engineering.The figures show microcomputed tomographic images of regenerated periodontium (tooth supporting structures) following delivery of PDGF genes.Gene therapy is an accepted, viable therapeutic concept, but safety is a major hurdle,...

2009-04-02 14:57:32

Life-threatening cardiac arrhythmia can be a consequence of myocarditis "“ an inflammation of the cardiac muscle that can be caused by the Coxsackievirus. In mice, Dr. Yu Shi, Chen Chen, and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now abolished the infection by blocking the receptor which is required for virus entry. "We did not detect a single cardiomyocyte that was infected by the virus. Inflammation of the heart...


Latest Adenoviridae Reference Libraries

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2011-01-05 16:00:36

Human parainfluenza viruses, belonging to the paramyxovirus family, are a group of four distinct serotypes of enveloped single-stranded RNA viruses. They are the second most common cause of lower respiratory tract infection in younger children. Many times the host has repeat infections throughout life with symptoms that may include upper respiratory tract illness or more commonly, a cold and sore throat. It can also cause severe pneumonia in immunosuppressed people. There is currently no...

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Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.