Latest Adenoviridae Stories
New research from The Children's Hospital of Philadelphia sheds light on the role of cell receptors in acting as gatekeepers for infectious viruses
PHILADELPHIA, July 22 /PRNewswire-USNewswire/ -- New research from The Children's Hospital of Philadelphia sheds light on the role of cell receptors in acting as gatekeepers for infectious viruses.
EMERYVILLE, Calif. and HUENENBERG, Switzerland, July 5 /PRNewswire-FirstCall/ -- Alcon, Inc. (NYSE: ACL) and its partner, NovaBay Pharmaceuticals, Inc.
Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR).
Specially designed virus-derived vectors â€“ engineered not to cause disease â€“ can take therapeutic genes to the malfunctioning peripheral neurons outside the spinal cord and brain, alleviating the pain and other dysfunction that can result from a chronic disease or drug treatment.
Sensory neuronopathies, nerve dysfunction that affects nerves outside the brain and spinal chord, are extremely painful.
Medical conditions that affect sensory nerves outside the brain and spinal cord are known as sensory neuronopathies. These conditions, which are extremely painful, include shingles and can be caused by anticancer drugs such as cisplatin.
Human trials of a virus that kills cancer cells in mice without harming healthy cells is at least two years away, British researchers said. An adenovirus that causes chest infections was modified to deliver genetic therapy to liver tumors in mice without poisoning healthy tissue, said Leonard Seymour, a cancer researcher at the University of Oxford. The approach we developed is easy to use and flexible, Seymour said.
Scientists have determined how to produce replication-competent viruses with key toxicities removed, providing a new platform for development of improved cancer treatments and better vaccines for a broad range of viral diseases.
Many proteins do not function by themselves as stand-alone units. Instead, multiple proteins associate to form larger structures called protein complexes.
Human parainfluenza viruses, belonging to the paramyxovirus family, are a group of four distinct serotypes of enveloped single-stranded RNA viruses. They are the second most common cause of lower respiratory tract infection in younger children. Many times the host has repeat infections throughout life with symptoms that may include upper respiratory tract illness or more commonly, a cold and sore throat. It can also cause severe pneumonia in immunosuppressed people. There is currently no...
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