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2013-02-11 13:31:42

A lack of the protein endoglin in the blood vessels of tumor-bearing mice enables the spread of daughter tumors, according to researchers at Karolinska Institutet and Lund University in Sweden in a study published in the scientific periodical The Journal of Experimental Medicine. Given that the tumor vasculature constitutes an important barrier to the spread of cancer cells, the team suggests that drugs should be developed to strengthen the blood vessels' protective function. Studies of...

2012-04-09 09:51:29

Combining two strategies designed to improve the results of cancer treatment — antiangiogenesis drugs and nanomedicines — may only be successful if the smallest nanomedicines are used. A new study from Massachusetts General Hospital (MGH) researchers, appearing in Nature Nanotechnology, finds that normalizing blood vessels within tumors, which improves the delivery of standard chemotherapy drugs, can block the delivery of larger nanotherapy molecules. "We found that vascular...

2012-02-23 10:15:37

Researchers from UCLA's Jonsson Comprehensive Cancer Center, together with scientists from 12 other sites in the United States and Australia, report for the first time that a newly approved drug for patients with metastatic melanoma nearly doubles median survival times, a finding that will change the way this deadly form of skin cancer is treated. The data comes from an international Phase II study of Zelboraf that included 132 patients followed for at least one year. Patients with this...

2012-01-20 10:59:48

Novel imaging platform reveals new details on disease development When cancers become aggressive and spread they are the most deadly. Unfortunately, little is known about how to stop this development. A new imaging platform developed by Lawson Health Research Institute's Drs. Ann Chambers and John Lewis is providing insight into just that - the exact moment when cancer cells turn deadly. Certain proteins, such as E-cadherin, are important for the maintenance of normal tissue structure....

2012-01-18 06:29:54

(Ivanhoe Newswire) — A new study found that a group of little-explored cells in the tumor microenvironment can likely serve as gatekeepers against cancer progression and metastasis. One known way of treating cancer is by targeting angiogenesis, or blood vessel growth. Raghu Kalluri, MD, PhD, Chief of the Division of Matrix Biology at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School (HMS) and colleagues, hypothesized whether targeting a...

2011-12-21 19:32:59

Cell-surface protein N-cadherin represents a promising therapeutic target for the treatment of pancreatic cancer, say researchers at Jefferson's Center for Translational Medicine Often, and without much warning, pancreatic cancer cells slip through the endothelial cells, head into the blood and out to other parts of the body to metastasize, making it one of the deadliest and hardest to treat cancers today. Now, researchers from Thomas Jefferson University's Center for Translational...

2011-07-02 02:29:20

Natural plant compound blocks vessel growth by interfering with cellular adhesion Massachusetts General Hospital (MGH) researchers have discovered the first of an entirely new class of antiangiogenesis drugs "“ agents that interfere with the development of blood vessels. In a report in Proceedings of the National Academy of Sciences/Early Edition, the investigators describe how a compound derived from a South American tree was able, through a novel mechanism, to interfere with blood...

2011-03-29 13:26:11

Study shows drug effectively shrank tumors, caused few side effects in animals Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug called AT-406 with potential to treat multiple types of cancer. A study, published this week in the Journal of Medicinal Chemistry, showed that AT-406 effectively targets proteins that block normal cell death from occurring. Blocking these proteins caused tumor cells to die, while not harming normal cells. The...

2010-12-13 20:55:09

A remarkable discovery into how tumor cells invade normal tissue should lead to vital diagnostic tools and help develop strategies to stop the spread of cancer cells. A new study by scientists at the Montreal Neurological Institute and Hospital of McGill University reveals that the surface of aggressive tumor cells lack the strong molecular "Ëœglue' responsible for binding normal cells together. This allows tumor cells to break away, detach from their neighbors, and spread to other...

2009-03-11 14:54:25

Researchers have identified a drug combination that shows promise in attacking deadly melanoma. By targeting and disabling a protein frequently found in melanoma tumors, doctors may be able to make the cancer more vulnerable to chemotherapy. The early results appear in a clinical study conducted by researchers in the Duke Comprehensive Cancer Center. Doctors gave patients with extremely advanced melanoma a compound that had been shown in pre-clinical studies to weaken tumors. Researchers...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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