Quantcast
Last updated on April 23, 2014 at 21:24 EDT

Latest Agouti-related peptide Stories

2013-03-26 11:05:54

Neurons that control hunger in the central nervous system also regulate immune cell functions, implicating eating behavior as a defense against infections and autoimmune disease development, Yale School of Medicine researchers have found in a new study published in the Proceedings of the National Academy of Sciences (PNAS). Autoimmune diseases have been on a steady rise in the United States. These illnesses develop when the body's immune system turns on itself and begins attacking its own...

2012-09-18 23:11:20

The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed. A lack of AgRP-neurons, brain cells known to be involved in the control of food intake, leads to obesity if mice are fed a regular carbohydrate diet. However, animals that are deficient in AgRP-neurons but which are raised on a high-fat diet are leaner and healthier. The differences...

Appetite Control With New Brain Receptor
2012-06-08 06:08:39

Connie K. Ho for redOrbit.com Losing weight and eating healthier have gone hand-in-hand for some time. Researchers from Columbia University Medical Center (CUMC) recently discovered how to help people in their goals for weight loss; a brain receptor that was found to have abilities to help regulate appetite. The study, published in the online edition of Cell, could help create new drugs focused on combating obesity. "We've identified a receptor that is intimately involved in...

2011-03-02 01:59:54

In the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behavior. Agouti-related protein (AgRP) neurons express three proteins that have been implicated in changes in energy balance, but the studies linking AgRP neurons to feeding behavior have produced mixed results. To directly analyze the role of AgRP neurons, Bradford Lowell and colleagues, at Beth Israel Deaconess Medical Center in Boston, used DREADD technology (designer receptors...

2011-01-04 15:22:17

Researchers at the University of Colorado School of Medicine have created a new and exciting mouse model to study how lipid sensing and metabolism in the brain relate to the regulation of energy balance and body weight. The research team, led by Hong Wang, PhD, created mice with a deficiency of lipoprotein lipase (LPL) in neurons, and observed two important reactions. First, the mouse models ate less and second, they became sedentary. Because LPL is important to the delivery of fatty acids to...

cd9f292bc56f0abdbd2ad8e308dd53151
2010-10-30 12:45:46

Researchers led by Vanderbilt's Roger Cone, Ph.D., have discovered a new member of a gene family that has powerful influences on pigmentation and the regulation of body weight.The gene is the third member of the agouti family. Two agouti genes have been identified previously in humans. One helps determine skin and hair color, and the other may play an important role in obesity and diabetes. The new gene, called agrp2, has been found exclusively in bony fish, including zebrafish, trout and...

2009-07-21 12:39:36

The peptide alpha-MSH works in a region of the brain known as the hypothalamus to suppress appetite. A team of researchers, at Yale University School of Medicine, New Haven, and the University of California Davis, has provided new insight into the way in which levels of the active form of alpha-MSH are regulated in mice. Specifically, genetic and biochemical analysis performed by the team, led by Sabrina Diano and Craig Warden, indicated that the protein PRCP is expressed in the hypothalamus...

2009-06-02 14:26:54

Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic"”not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that blood sugar control in those animals can be completely restored by returning leptin sensitivity to a single class of neurons in the brain, which account for only a small fraction of those that normally carry the hormone receptors."Just the receptors in this little group of neurons are...