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Latest Ajit Varki Stories

2014-04-08 10:43:57

The difference between an immune response that kills cancer cells and one that conversely stimulates tumor growth can be as narrow as a "double-edged sword," report researchers at the University of California, San Diego School of Medicine in the April 7, 2014 online issue of the Proceedings of the National Academy of Sciences. "We have found that the intensity difference between an immune response that stimulates cancer and one that kills it may not be very much," said principal...

Infectious Diseases Determined Current Gene Makeup
2012-06-05 08:08:25

Connie K. Ho for redOrbit.com The author J.J. Dewey once said, "Consciousness cannot live in the present for the present cannot exist without the future and the past." This idea of the past influencing the present was seen in a recent report published in the online Early Edition of the Proceedings of the National Academy of Sciences that proposed that the inactivation of two genes linked to the immune system could have given some ancestors of modern humans greater protection from specific...

Image 1 - Sexual Selection By Sugar Molecule Helped Determine Human Origins
2011-10-11 03:46:42

Researchers at the University of California, San Diego School of Medicine say that losing the ability to make a particular kind of sugar molecule boosted disease protection in early hominids, and may have directed the evolutionary emergence of our ancestors, the genus Homo. The findings, published in this week's early online edition of the Proceedings of the National Academy of Sciences, are among the first evidence of a novel link between cell surface sugars, Darwinian sexual selection,...

2011-04-19 16:47:05

UC San Diego researchers finds promise in non-human sialic acid antibodies Researchers at the University of California, San Diego School of Medicine say antibodies to a non-human sugar molecule commonly found in people may be useful as a future biomarker for predicting cancer risk, for diagnosing cancer cases early and, in sufficient concentration, used as a treatment for suppressing tumor growth. The work was led by Richard Schwab, MD, assistant clinical professor of medicine, and Ajit...

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2011-02-25 08:33:16

Researchers at the University of California, San Diego School of Medicine and Rady Children's Hospital-San Diego say an evolutionary gene mutation that occurred in humans millions of years ago and our subsequent inability to produce a specific kind of sialic acid molecule appears to make people more vulnerable to developing type 2 diabetes, especially if they're overweight. The findings are published in the Feb. 24 online edition of The FASEB Journal, a publication of the Federation of...

2010-09-11 02:10:21

The glycome, encompassing all of the complex sugars produced by an organism, is comprised of multiple families of molecules whose function in the human body is often determined by the structure, composition, and placement of the attached sugars, as explored in a comprehensive look at the field of glycomics in a group of key articles in OMICS: A Journal of Integrative Biology, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The relevant articles are available...

2010-07-26 12:10:58

Researchers at the University of California, San Diego School of Medicine have discovered that a kind of sugar molecule common to chimpanzees, gorillas and other mammals but not found in humans provokes a strong immune response in some people, likely worsening conditions in which chronic inflammation is a major issue. This non-human sialic acid sugar is an ingredient in some biotechnology drugs, and may be limiting or undermining their therapeutic effectiveness in some patients, the...

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2009-07-13 10:55:00

Group B Streptococcus (GBS), a bacterial pathogen that causes sepsis and meningitis in newborn infants, is able to shut down immune cell function in order to promote its own survival, according to researchers at the University of California, San Diego School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Their study, published online July 13 in the Journal of Experimental Medicine, offers insight into GBS infection "“ information that may lead to new medical...

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2008-11-14 10:30:00

Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors. Their findings, which suggest that inflammation resulting from a molecule introduced through consumption of these foods could promote tumor growth, are published online this week in advance of print publication in the Proceedings of the National Academy...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.