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Latest Alcohol dehydrogenase Stories

Sprite Cures Hangovers
2013-10-10 12:36:32

[ Watch the Video: Hangover? Drink Sprite ] Lee Rannals for redOrbit.com - Your Universe Online Chinese scientists have determined that one popular lemon-lime soft drink may be the best cure for a hangover. In a study published in the journal Food and Function, experts say that Sprite may be the best thing for combating the that brutal hangover after a late night of partying, even more than a cup of black coffee or a Bloody Mary. "Various alcoholic beverages containing different...

2011-09-15 20:55:48

Alcohol is known to be carcinogenic to humans in the upper aerodigestive tract, liver, colorectum, and the female breast. Evidence suggests that acetaldehyde, the primary metabolite of alcohol, plays a major role in alcohol-related esophageal cancer. A new study using human cells has established linkages between alcohol metabolism and acetaldehyde-DNA damage that may have implications for breast and liver cancers. Results will be published in the December 2011 issue of Alcoholism: Clinical...

2011-08-16 12:22:42

    * Gender differences exist in the prevalence, characteristics, and course of alcohol dependence (AD).    * Polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are strong genetic determinants of AD.    * While inactive ALDH2 traditionally delays the development of AD in men, a new study has found that inactive ALDH2 can accelerate the development of AD in women. Researchers know that gender differences exist in...

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2011-04-05 06:15:00

Scientists have identified a gene that appears to play a role in regulating how much alcohol people drink, a finding researchers say could someday lead to better treatments for alcoholism. The gene, known as "autism susceptibility candidate 2", or AUTS2, has previously been linked to autism and attention deficit hyperactivity disorder (ADHD), although its precise function is not understood.  It is most active in parts of the brain associated with neuropsychological reward mechanisms,...

2010-05-05 14:41:49

Genetic differences in alcohol-metabolizing enzymes can significantly alter an individual's risk for developing alcohol dependence (AD). One variant of the alcohol dehydrogenase enzyme, ADH1B*3, is observed almost exclusively in populations with African ancestry and has also been associated with reduced rates of AD. A new study has found that greater levels of sedation in African Americans with ADH1B*3 may explain their lower rates of AD. Results will be published in the July 2010 issue of...

2009-10-27 09:13:29

Alcohol abuse is a leading cause of liver cirrhosis in Mexico. Given that genetics likely play a role in high rates of alcoholic liver disease, researchers analyzed the polymorphisms of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2) and cytochrome P4502E1 (CYP2E1) in two groups in Mexico: the Mestizos, those with mixed genes, and the Huichols, an indigenous group with no racial admixture. Findings show the Huichols have the highest CYP2E1*c2 allele frequency documented in the...

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2009-06-28 13:02:41

Alcohol's inebriating effects are familiar to everyone. But the molecular details of alcohol's impact on brain activity remain a mystery. A new study by researchers at the Salk Institute for Biological Studies brings us closer to understanding how alcohol alters the way brain cells work. Their findings, published in the current advance online edition of Nature Neuroscience, reveal an alcohol trigger site located physically within an ion channel protein; their results could lead to the...

2008-11-13 06:00:36

Raptor Pharmaceuticals, a development-stage biotechnology company, has announced positive results in its Phase IIa study of oral 4-methylpyrazole in subjects with aldehyde dehydrogenase deficiency, or ethanol intolerance, as the initial development stage of its Convivia program. Convivia is Raptor's proprietary oral formulation of 4-methylpyrazole (4-MP) designed to reduce systemic acetaldehyde exposure and related symptoms in aldehyde dehydrogenase (ALDH2) deficient persons following...

2008-11-11 12:00:06

NOVATO, Calif., Nov. 11 /PRNewswire-FirstCall/ -- Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") (BULLETIN BOARD: RPTP) , today announced positive results in its Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM) program. Convivia(TM) is Raptor's proprietary oral formulation of 4-MP designed to reduce systemic acetaldehyde exposure and related symptoms in ALDH2 deficient...

2008-09-09 03:00:06

By Venkataranganna, M V Gopumadhavan, S; Sundaram, R; Peer, Ghouse; Mitra, S K Background & objectives: PartySmart is a herbal preparation intended for the management of alcohol hangover and other related toxic effects in clinical situation. The present study was designed to investigate the pharmacodynamics and oral toxicity of PartySmart, a herbal formulation in rats. Methods: Effect of PartySmart on blood acetaldehyde and alcohol levels was evaluated at doses of 125, 250 and 500 mg/kg...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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