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Latest Aldehyde dehydrogenase Stories

2012-03-22 22:44:15

Many observational cohort studies have shown that moderate alcohol use is associated with better cognitive function. However, since such studies are vulnerable to residual confounding by other lifestyle and physiologic factors, the authors conducted a Mendelian randomization study, using aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis. Cognitive function was assessed from delayed 10-word recall score (n = 4,707) and...

2011-09-16 05:28:24

(Ivanhoe Newswire) -- Next time you reach for a drink, you may need to consider side effects other than a rough morning. A new study that will be published in the December 2011 issue of Alcoholism: Clinical & Experimental Research has established a link between alcohol metabolism and DNA damage that may cause breast and liver cancers. Alcohol is known to be carcinogenic to humans in the upper aero digestive tract, liver, colon, and the female breast. "Although the link between...

2011-09-15 20:55:48

Alcohol is known to be carcinogenic to humans in the upper aerodigestive tract, liver, colorectum, and the female breast. Evidence suggests that acetaldehyde, the primary metabolite of alcohol, plays a major role in alcohol-related esophageal cancer. A new study using human cells has established linkages between alcohol metabolism and acetaldehyde-DNA damage that may have implications for breast and liver cancers. Results will be published in the December 2011 issue of Alcoholism: Clinical...

2011-08-16 12:22:42

    * Gender differences exist in the prevalence, characteristics, and course of alcohol dependence (AD).    * Polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are strong genetic determinants of AD.    * While inactive ALDH2 traditionally delays the development of AD in men, a new study has found that inactive ALDH2 can accelerate the development of AD in women. Researchers know that gender differences exist in...

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2011-01-07 11:09:39

A vaccine to combat alcoholism will begin human testing next year, claim Chilean researchers. The genetic therapy is based on aldehyde dehydrogenase, a group of enzymes that metabolize alcohol and are thus responsible for alcohol tolerance, Professor Juan Asenjo told the AFP news agency. Asenjo heads a team of researchers at Chile's Faculty of Sciences and Mathematics and the private lab Recalcine. In October, US researchers announced they had discovered a gene variation known as CYP2EI that...

2010-05-05 14:41:49

Genetic differences in alcohol-metabolizing enzymes can significantly alter an individual's risk for developing alcohol dependence (AD). One variant of the alcohol dehydrogenase enzyme, ADH1B*3, is observed almost exclusively in populations with African ancestry and has also been associated with reduced rates of AD. A new study has found that greater levels of sedation in African Americans with ADH1B*3 may explain their lower rates of AD. Results will be published in the July 2010 issue of...

2010-01-10 13:16:44

An experimental compound repaired a defective alcohol metabolism enzyme that affects an estimated 1 billion people worldwide, according to research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The findings, published Jan. 10, 2010 in the advance online edition of Nature Structural and Molecular Biology, suggest the possibility of a treatment to reduce the health problems associated with the enzyme defect. "This intriguing finding could have broad public health...

2009-10-27 09:13:29

Alcohol abuse is a leading cause of liver cirrhosis in Mexico. Given that genetics likely play a role in high rates of alcoholic liver disease, researchers analyzed the polymorphisms of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2) and cytochrome P4502E1 (CYP2E1) in two groups in Mexico: the Mestizos, those with mixed genes, and the Huichols, an indigenous group with no racial admixture. Findings show the Huichols have the highest CYP2E1*c2 allele frequency documented in the...

2009-08-18 15:46:15

The reaction causing bioactivation is not well understoodSo-called nitrovasodilators such as nitroglycerin have been used effectively in the treatment of angina pectoris in coronary heart disease for more than century. Within the human body, nitric oxide (NO) is released from the nitroglycerin and in turn stimulates an enzyme that dilates the arteries and thus improves blood circulation. In 1998, Robert F. Furchgott, Ferid Murad and Louis Ignarro were awarded the Nobel Prize for Medicine for...

2009-03-25 09:38:34

If your face gets flushed when you drink alcohol, you could be in danger of developing esophageal cancer. Researchers said facial flushing after drinking is predominately caused by an inherited deficiency in an enzyme called aldehyde dehydrogenase 2, or ALDH2. There is growing evidence that ALDH2-deficient people are at a much higher risk of esophageal cancer, specifically squamous cell carcinoma, from alcohol consumption than those individuals with fully active ALDH-2. Doctors from the...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.