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Latest Aldehyde dehydrogenase Stories

2008-11-13 06:00:36

Raptor Pharmaceuticals, a development-stage biotechnology company, has announced positive results in its Phase IIa study of oral 4-methylpyrazole in subjects with aldehyde dehydrogenase deficiency, or ethanol intolerance, as the initial development stage of its Convivia program. Convivia is Raptor's proprietary oral formulation of 4-methylpyrazole (4-MP) designed to reduce systemic acetaldehyde exposure and related symptoms in aldehyde dehydrogenase (ALDH2) deficient persons following...

2008-11-11 12:00:06

NOVATO, Calif., Nov. 11 /PRNewswire-FirstCall/ -- Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") (BULLETIN BOARD: RPTP) , today announced positive results in its Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM) program. Convivia(TM) is Raptor's proprietary oral formulation of 4-MP designed to reduce systemic acetaldehyde exposure and related symptoms in ALDH2 deficient...

2008-09-11 15:00:11

Marauding molecules cause the tissue damage that underlies heart attacks, sunburn, Alzheimer's and hangovers. But scientists at the Stanford University School of Medicine say they may have found ways to combat the carnage after discovering an important cog in the body's molecular detoxification machinery. The culprit molecules are oxygen byproducts called free radicals. These highly unstable molecules start chain reactions of cellular damage -- an escalating storm that ravages healthy...

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2008-03-04 11:40:00

British researchers report that people who regularly consume alcohol, even in moderate amounts, have higher blood pressure than those who do not drink.  The study further revealed that those with a genetic mutation that makes it difficult to consume alcohol had substantially lower blood pressure than regular or heavy drinkers. The scientists, led by Sarah Lewis at the University of Bristol, UK, examined the results of five published studies on the association between blood pressure and...

2007-10-02 09:01:00

By De Muynck, Cassandra Pereira, Catarina S S; Naessens, Myriam; Parmentier, Sofie; Et al ABSTRACT The genus Gluconobacter comprises some of the most frequently used microorganisms when it comes to biotechnological applications. Not only has it been involved in "historical" production processes, such as vinegar production, but in the last decades many bioconversion routes for special and rare sugars involving Gluconobacter have been developed. Among the most recent are the...

2005-07-14 15:35:00

- Alcohol consumption is an integral part of the Japanese business culture. - Many East Asians have a mutant form of aldehyde dehydrogenase (ALDH), which is a key enzyme in the elimination of alcohol-induced acetaldehyde. - Individuals with inactive ALDH2 do not appear to be able to eliminate acetaldehyde from their systems, which increases their susceptibility to hangovers. Alcohol consumption is an integral part of the Japanese business culture. Hangovers, however, can have substantial...

2005-07-15 12:38:23

This mutation is no party, Japanese team say HealthDay News -- Many hangover sufferers looking for someone or something to blame can now point the finger at their own genes, according to a new study. Mutations in a specific gene inactivate a key enzyme and slow the elimination of acetaldehyde -- the first product of alcohol metabolism -- from the body, say Japanese researchers reporting in the July issue of Alcoholism: Clinical & Experimental Research. Their study of 326 Japanese female...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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