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Latest ALDH2 Stories

2011-09-16 05:28:24

(Ivanhoe Newswire) -- Next time you reach for a drink, you may need to consider side effects other than a rough morning. A new study that will be published in the December 2011 issue of Alcoholism: Clinical & Experimental Research has established a link between alcohol metabolism and DNA damage that may cause breast and liver cancers. Alcohol is known to be carcinogenic to humans in the upper aero digestive tract, liver, colon, and the female breast. "Although the link between...

2011-09-15 20:55:48

Alcohol is known to be carcinogenic to humans in the upper aerodigestive tract, liver, colorectum, and the female breast. Evidence suggests that acetaldehyde, the primary metabolite of alcohol, plays a major role in alcohol-related esophageal cancer. A new study using human cells has established linkages between alcohol metabolism and acetaldehyde-DNA damage that may have implications for breast and liver cancers. Results will be published in the December 2011 issue of Alcoholism: Clinical...

2011-08-16 12:22:42

    * Gender differences exist in the prevalence, characteristics, and course of alcohol dependence (AD).    * Polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are strong genetic determinants of AD.    * While inactive ALDH2 traditionally delays the development of AD in men, a new study has found that inactive ALDH2 can accelerate the development of AD in women. Researchers know that gender differences exist in...

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2010-01-10 15:36:53

Researchers at the Indiana University and Stanford University schools of medicine have determined how a "chemical chaperone" does its job in the body, which could lead to a new class of drugs to help reduce the muscle damage caused by heart attacks. Such drugs would work by restoring the activity of a mutated enzyme, rather than taking the more common approach of blocking the actions of a disease-related protein. The team, led by Thomas Hurley, Ph.D., associate chair and professor of...

2010-01-10 13:16:44

An experimental compound repaired a defective alcohol metabolism enzyme that affects an estimated 1 billion people worldwide, according to research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The findings, published Jan. 10, 2010 in the advance online edition of Nature Structural and Molecular Biology, suggest the possibility of a treatment to reduce the health problems associated with the enzyme defect. "This intriguing finding could have broad public health...

2009-10-27 09:13:29

Alcohol abuse is a leading cause of liver cirrhosis in Mexico. Given that genetics likely play a role in high rates of alcoholic liver disease, researchers analyzed the polymorphisms of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2) and cytochrome P4502E1 (CYP2E1) in two groups in Mexico: the Mestizos, those with mixed genes, and the Huichols, an indigenous group with no racial admixture. Findings show the Huichols have the highest CYP2E1*c2 allele frequency documented in the...

2009-08-18 15:46:15

The reaction causing bioactivation is not well understoodSo-called nitrovasodilators such as nitroglycerin have been used effectively in the treatment of angina pectoris in coronary heart disease for more than century. Within the human body, nitric oxide (NO) is released from the nitroglycerin and in turn stimulates an enzyme that dilates the arteries and thus improves blood circulation. In 1998, Robert F. Furchgott, Ferid Murad and Louis Ignarro were awarded the Nobel Prize for Medicine for...

2008-11-13 06:00:36

Raptor Pharmaceuticals, a development-stage biotechnology company, has announced positive results in its Phase IIa study of oral 4-methylpyrazole in subjects with aldehyde dehydrogenase deficiency, or ethanol intolerance, as the initial development stage of its Convivia program. Convivia is Raptor's proprietary oral formulation of 4-methylpyrazole (4-MP) designed to reduce systemic acetaldehyde exposure and related symptoms in aldehyde dehydrogenase (ALDH2) deficient persons following...

2008-11-11 12:00:06

NOVATO, Calif., Nov. 11 /PRNewswire-FirstCall/ -- Raptor Pharmaceuticals Corp. ("Raptor" or the "Company") (BULLETIN BOARD: RPTP) , today announced positive results in its Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM) program. Convivia(TM) is Raptor's proprietary oral formulation of 4-MP designed to reduce systemic acetaldehyde exposure and related symptoms in ALDH2 deficient...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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