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Latest Ali Shilatifard Stories

2014-01-16 14:30:04

Application of global sequencing technology reveals how an activator of gene expression stays focused At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either coil DNA into inaccessible silent regions or untwist it to allow gene expression. To further complicate things, small chemical flags, such as...

Fruit Fly Studies Guide Researchers To Misregulated Mechanism In Human Cancers
2012-11-19 15:21:04

Stowers Institute for Medical Research Changes in how DNA interacts with histones–the proteins that package DNA–regulate many fundamental cell activities from stem cells maturing into a specific body cell type or blood cells becoming leukemic. These interactions are governed by a biochemical tug of war between repressors and activators, which chemically modify histones signaling them to clamp down tighter on DNA or move aside and allow a gene to be expressed. In the November...

2011-12-22 15:35:16

Transcriptional elongation control takes on new dimensions as Stowers researchers find gene class-specific elongation factors Life is complicated enough, so you can forgive the pioneers of DNA biology for glossing over transcriptional elongation control by RNA polymerase II, the quick and seemingly bulletproof penultimate step in the process that copies the information encoded in our DNA into protein-making instructions carried by messenger RNA. In a new report appearing in the Dec. 23,...

2009-04-02 13:12:29

U.S. scientists say they have proposed a definition of epigenetics -- a new research field focusing on heritable genetic alterations not caused by DNA. Ali Shilatifard of the Stowers Institute for Medical Research met with colleagues in December at the Cold Spring Harbor Laboratory in New York to develop a consensus definition of epigenetic traits for consideration by the broader research community. Shilatifard said the definition is intended to address confusion within the scientific...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.