Latest Allodynia Stories

2014-03-07 16:22:40

PHOENIX, March 7, 2014 /PRNewswire-USNewswire/ -- Researchers have demonstrated that conditioned pain modulation (CPM), a measure of the brain's ability to regulate pain, decreases activity in the human spinal cord as visible via functional magnetic resonance imaging (fMRI). "This study confirmed our hypothesis that CPM results in significant reductions in spinal dorsal horn activity in humans," said lead study author Ian Mackey, of Stanford University in Palo Alto, Calif. The...

2012-12-28 15:28:26

Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could have major implications for future treatment of this often-debilitating condition. “Clinically, scientists have focused on trying to understand how cartilage and joints degenerate in osteoarthritis. But no one knows why it hurts,” said Dr. Anne-Marie...

2012-10-15 16:35:50

Companionship has the potential to reduce pain linked to nerve damage, according to a new study. Mice that were paired with a cage-mate showed lower pain responses and fewer signs of inflammation in their nervous system after undergoing surgery that affected their nerves than did isolated mice, suggesting that the social contact had both behavioral and physiological influences. The social contact lowered the pain response and signs of inflammation even in animals that had experienced...

2011-12-15 16:26:29

A discovery in fruit flies may be able to tell us more about how animals, including humans, sense potentially dangerous discomforts. Researchers at Duke University Medical Center uncovered naturally occurring variations of a gene named TRPA1 that is important for the function of pain-sensing neurons throughout the animal kingdom. The gene makes an ion channel, which floods sensory neurons with calcium ions when the fly is near a heat source, causing fruit fly larvae to respond with a...

2010-06-17 13:45:00

Cold sensing neural circuits in newborn mice take around two weeks to become fully active, according to a new study. The finding adds to understanding of the cold sensing protein TRPM8 (pronounced trip-em-ate), first identified in a Nature paper in 2002 by USC College professor David McKemy. McKemy's study, published online by Neuroscience, shows that the cold sensing circuit starts to develop in utero but does not mature until well after birth. "About three or four days before the animal is...

2010-04-14 06:00:00

MOUNTAIN VIEW, Calif., April 14 /PRNewswire-FirstCall/ -- MAP Pharmaceuticals, Inc. (Nasdaq: MAPP) today announced additional post-hoc analyses of data from the FREEDOM-301 Phase 3 trial of its investigational LEVADEX(TM) orally inhaled migraine therapy showing efficacy in two difficult to treat patient subpopulations, menstrual migraine and migraine with allodynia. The data will be presented at the Annual Meeting of the American Academy of Neurology (AAN) in Toronto, Ontario. As...

2009-08-13 15:45:00

Research has implications for medical use of drug and concepts of chronic pain Imagine that you're working on your back porch, hammering in a nail. Suddenly you slip and hit your thumb instead "” hard. The pain is incredibly intense, but it only lasts a moment. After a few seconds (and a few unprintable words) you're ready to start hammering again.How can such severe pain vanish so quickly? And why is it that other kinds of equally terrible pain refuse to go away, and instead...

Word of the Day
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.