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Latest Alpha-synuclein Stories

2010-09-20 22:18:48

A protein linked to Parkinson's disease may cause neurodegeneration by inhibiting autophagy"”the process in which cells digest some of their contents"”according to a study in the September 20 issue of the Journal of Cell Biology (www.jcb.org). Autophagy serves to clear a variety of toxic waste from cells, including misfolded proteins and defective mitochondria. These two types of cellular trash accumulate in neurons from Parkinson's patients, suggesting that autophagy could be...

2010-09-10 12:09:20

Yeast could be a powerful ally in the discovery of new therapeutic drugs to treat Parkinson's disease says a scientist presenting his work at the Society for General Microbiology's autumn meeting in Nottingham today. Dr Tiago Fleming Outeiro from the Instituto de Medicina Molecular in Lisbon, Portugal describes how his group is slowly uncovering the molecular basis of Parkinson's disease by studying the associated human protein in yeast cells. Parkinson's disease is a neurodegenerative...

2010-07-06 12:00:00

NEW YORK, July 6 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research today announced nearly $1.1 million for projects aimed at advancing the development of leading biomarker candidates for Parkinson's disease. The discovery and validation of biomarkers is of critical importance to increasing the speed and efficiency of PD therapeutic development, allowing scientists and clinicians to more accurately identify appropriate subjects for clinical studies, measure...

2010-06-16 14:05:00

UC San Diego researchers say too much alpha-synuclein shuts down cell communications, helps cause dementia In diverse neurodegenerative diseases ranging from Parkinson's to Alzheimer's, researchers have long noted accumulations of a little-understood neuronal protein called ÃŽ±-synuclein. Pathological and genetic evidence strongly suggested that excessive ÃŽ±-synuclein played a role in the evolution of these diseases, but it was unclear how too much...

2010-04-23 10:44:00

NEW YORK, April 23 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research today announced more than $3 million in previously unannounced awards ending the first quarter of 2010. The funded projects complement the Foundation's annually occurring Pipeline Programs and Critical Challenges in Parkinson's Disease initiatives, which aim to accelerate PD therapeutic development. Many of the 17 different projects announced today provide additional funding to advance...

2010-03-02 14:15:00

NEW YORK, March 2 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research announced up to $5.75 million in total funding available under its three 2010 Critical Challenges. Each year the Foundation tailors specific Challenges to advance one or more of its key research priorities in PD drug development: forging new strategies to define Parkinson's disease and its progression, alter disease course, reduce symptoms and complications of treatment to increase quality...

2010-02-09 16:35:00

NEW YORK, Feb. 9 /PRNewswire-USNewswire/ -- As part of its mission to do whatever it takes to speed development of life-transforming treatments and a cure for Parkinson's disease, The Michael J. Fox Foundation announced $1 million in total funding for seven research projects aiming to push forward critical research tools and new technologies to accelerate PD therapeutic development. While new genetic and cellular targets have invigorated Parkinson's research over the past decade,...

2010-01-19 14:00:00

NEW YORK, Jan. 19 /PRNewswire-USNewswire/ -- As part of its mission to speed development of transformative treatments for Parkinson's disease, The Michael J. Fox Foundation for Parkinson's Research announced a total of $2.1 million in awards to six biotech and pharmaceutical companies under its industry-exclusive Therapeutics Development Initiative (TDI). The funding will drive pre-clinical projects pushing forward investigations of promising neuroprotective therapeutic targets for...

2009-12-28 16:59:32

FINDINGS: Several structurally similar small molecules appear capable of protecting cells from alpha-synuclein toxicity, a hallmark of Parkinson's disease. RELEVANCE: Parkinson's disease is a neurodegenerative disorder characterized by tremors, muscle rigidity, and slowed movements. There is currently no cure for the disease, and current Parkinson's therapies only address disease symptoms, not the disease's cellular cause. Small molecules found to protect cells in multiple models of...

2009-12-15 13:00:00

NEW YORK, Dec. 15 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation announced $1.7 million in funding to drive new and continuing Parkinson's research projects at the Banner Sun Health Research Institute and Mayo Clinic Arizona, sites of the Arizona Parkinson's Disease Consortium. Of the total funding, $1.1 million represents renewed funding for directed projects led by principal investigators Charles Adler, MD, PhD, at Mayo Clinic Arizona and Thomas Beach, MD, PhD, at Banner Sun...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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