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Latest Alpha-synuclein Stories

2009-12-15 13:00:00

NEW YORK, Dec. 15 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation announced $1.7 million in funding to drive new and continuing Parkinson's research projects at the Banner Sun Health Research Institute and Mayo Clinic Arizona, sites of the Arizona Parkinson's Disease Consortium. Of the total funding, $1.1 million represents renewed funding for directed projects led by principal investigators Charles Adler, MD, PhD, at Mayo Clinic Arizona and Thomas Beach, MD, PhD, at Banner Sun...

2009-12-10 15:27:00

NEW YORK, Dec. 10 /PRNewswire-USNewswire/ -- As part of its mission to accelerate promising therapeutic targets through the development pipeline toward clinical trials and, ultimately, patient care, The Michael J. Fox Foundation for Parkinson's Research (MJFF) announced that it has awarded a total of $1.3 million to nine research teams working to develop potentially disease-modifying therapies for Parkinson's disease. Research into disease-modifying therapies is a key priority for MJFF,...

2009-10-13 10:47:19

Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. Previous studies have indicated that phosphorylation of alpha-synuclein at amino acid 129 (Ser129) is a key event in alpha-synuclein"“mediated nerve cell toxicity. However, Mel Feany and colleagues, at Brigham and Women's Hospital, Boston, have now identified a counterbalancing role in nerve cell protection for phosphorylation of alpha-synuclein amino acid 125 (Tyr125). In the...

2009-08-01 07:51:01

Parkinson's disease is well-known for impairing movement and causing tremors, but many patients also develop other serious problems, including sleep disturbances and significant losses in cognitive function known as dementia. Now researchers at Washington University School of Medicine in St. Louis have modeled Parkinson's-associated dementia for the first time. Scientists showed that a single night of sleep loss in genetically altered fruit flies caused long-lasting disruptions in the flies'...

2009-07-28 09:00:00

Accumulation of the synaptic protein alpha-synuclein, resulting in the formation of aggregates called Lewy bodies in the brain, is a hallmark of Parkinson's and other related neurodegenerative diseases. This pathology appears to spread throughout the brain as the disease progresses. Now, researchers at the University of California, San Diego School of Medicine and Konkuk University in Seoul, South Korea, have described how this mechanism works. Their findings "“ the first to show...

2009-07-13 13:07:28

Researchers funded by the National Institutes of Health have turned simple baker's yeast into a virtual army of medicinal chemists capable of rapidly searching for drugs to treat Parkinson's disease.In a study published online today in Nature Chemical Biology, the researchers showed that they can rescue yeast cells from toxic levels of a protein implicated in Parkinson's disease by stimulating the cells to make very small proteins called cyclic peptides. Two of the cyclic peptides had a...

2009-04-30 11:36:38

 In a study that reveals the clearest picture to date of neuron death in Parkinson's disease, researchers at Columbia University Medical Center have found that a trio of culprits acting in concert is responsible for killing the brain cells.The study, published in the April 30 issue of Neuron, showed that three molecules "“ the neurotransmitter dopamine, a calcium channel, and a protein called alpha-synuclein "“ act together to kill the neurons.The discovery gives researchers...

2009-04-02 12:31:22

Could provide target for therapy to treat Parkinson's disease, other neuro-degenerative diseasesA research team from the University of California, San Diego School of Medicine and the Salk Institute for Biological Studies in La Jolla has identified a protein in the brain of mice that protects neurons from excessive inflammation, which can lead to neurodegenerative disorders such as Parkinson's disease. Their study, which identifies the protective function of a protein called Nurr1 and defines...

2009-03-01 09:07:56

Teams of scientists from Australia and the United States have used yeast and mammalian cells to discover a connection between genetic and environmental causes of Parkinson's disease. Yeasts are single cell organisms, used widely in biological research because their structure resembles that of cells found in animals and humans. Yeasts share many genes, or their functional equivalents, with humans and offer the ability to screen or test thousands of genes and analyzing their effects. Two genes...

2009-02-26 13:45:00

KIRKLAND, Wash., Feb 26 /PRNewswire/ -- ProteoTech Inc. announced today that it has been awarded a grant from The Michael J. Fox Foundation for Parkinson's Disease Research. In collaboration with Avid Radiopharmaceuticals Inc. (Philadelphia, PA), ProteoTech scientists will utilize ProteoTech's small molecule platform drug technology to develop new imaging agents that will allow doctors to use PET imaging to identify and determine the extent of alpha-synuclein accumulation in the living human...


Word of the Day
out-herod
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.
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