Quantcast
Last updated on April 16, 2014 at 14:05 EDT

Latest Alpha-synuclein Stories

2009-07-28 09:00:00

Accumulation of the synaptic protein alpha-synuclein, resulting in the formation of aggregates called Lewy bodies in the brain, is a hallmark of Parkinson's and other related neurodegenerative diseases. This pathology appears to spread throughout the brain as the disease progresses. Now, researchers at the University of California, San Diego School of Medicine and Konkuk University in Seoul, South Korea, have described how this mechanism works. Their findings "“ the first to show...

2009-07-13 13:07:28

Researchers funded by the National Institutes of Health have turned simple baker's yeast into a virtual army of medicinal chemists capable of rapidly searching for drugs to treat Parkinson's disease.In a study published online today in Nature Chemical Biology, the researchers showed that they can rescue yeast cells from toxic levels of a protein implicated in Parkinson's disease by stimulating the cells to make very small proteins called cyclic peptides. Two of the cyclic peptides had a...

2009-04-30 11:36:38

 In a study that reveals the clearest picture to date of neuron death in Parkinson's disease, researchers at Columbia University Medical Center have found that a trio of culprits acting in concert is responsible for killing the brain cells.The study, published in the April 30 issue of Neuron, showed that three molecules "“ the neurotransmitter dopamine, a calcium channel, and a protein called alpha-synuclein "“ act together to kill the neurons.The discovery gives researchers...

2009-04-02 12:31:22

Could provide target for therapy to treat Parkinson's disease, other neuro-degenerative diseasesA research team from the University of California, San Diego School of Medicine and the Salk Institute for Biological Studies in La Jolla has identified a protein in the brain of mice that protects neurons from excessive inflammation, which can lead to neurodegenerative disorders such as Parkinson's disease. Their study, which identifies the protective function of a protein called Nurr1 and defines...

2009-03-01 09:07:56

Teams of scientists from Australia and the United States have used yeast and mammalian cells to discover a connection between genetic and environmental causes of Parkinson's disease. Yeasts are single cell organisms, used widely in biological research because their structure resembles that of cells found in animals and humans. Yeasts share many genes, or their functional equivalents, with humans and offer the ability to screen or test thousands of genes and analyzing their effects. Two genes...

2009-02-26 13:45:00

KIRKLAND, Wash., Feb 26 /PRNewswire/ -- ProteoTech Inc. announced today that it has been awarded a grant from The Michael J. Fox Foundation for Parkinson's Disease Research. In collaboration with Avid Radiopharmaceuticals Inc. (Philadelphia, PA), ProteoTech scientists will utilize ProteoTech's small molecule platform drug technology to develop new imaging agents that will allow doctors to use PET imaging to identify and determine the extent of alpha-synuclein accumulation in the living human...

6303bea7ad2be74189ebe5bee87c36b01
2009-02-23 08:08:51

A novel approach to analyzing cellular data is yielding new understanding of Parkinson's disease's destructive pathways. Whitehead Institute and Massachusetts Institute of Technology (MIT) scientists have employed this new computational technique to analyze alpha-synuclein, a mysterious protein that is associated with Parkinson's disease. Cells are constantly adapting to various stimuli, including changes in their environment and mutations, through an intricate web of molecular interactions....

2009-02-18 11:00:00

NEW YORK, Feb. 18 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research awarded approximately $1.9 million total to six teams working to develop neuroimaging technologies that would allow scientists to non-invasively visualize the clumping of the alpha-synuclein protein in the living human brain. Such technologies would dramatically accelerate research into the cause, progression and treatment of PD. Investigators could more accurately identify individuals with PD...

2009-02-02 14:58:30

U.S. researcher suggests there is a genetic link between Parkinson's disease and manganese poisoning. The study, published in Nature Genetics, ties Parkinson's disease to a protein in the brain -- alpha synuclien -- misfolding and forming clumps on the basis of how the protein behaves in the type of yeast used in baking and brewing. The similarity was discovered by Aaron Gitler -- studying yeast while at England's Whitehead Institute in Cambridge -- after reading about a type of Parkinson's...

2009-01-02 09:14:42

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells? One possible answer: by breaking a survival circuit called MEF2D. Researchers at Emory University School of Medicine have...