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Latest Alpha-synuclein Stories

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2009-02-23 08:08:51

A novel approach to analyzing cellular data is yielding new understanding of Parkinson's disease's destructive pathways. Whitehead Institute and Massachusetts Institute of Technology (MIT) scientists have employed this new computational technique to analyze alpha-synuclein, a mysterious protein that is associated with Parkinson's disease. Cells are constantly adapting to various stimuli, including changes in their environment and mutations, through an intricate web of molecular interactions....

2009-02-18 11:00:00

NEW YORK, Feb. 18 /PRNewswire-USNewswire/ -- The Michael J. Fox Foundation for Parkinson's Research awarded approximately $1.9 million total to six teams working to develop neuroimaging technologies that would allow scientists to non-invasively visualize the clumping of the alpha-synuclein protein in the living human brain. Such technologies would dramatically accelerate research into the cause, progression and treatment of PD. Investigators could more accurately identify individuals with PD...

2009-02-02 14:58:30

U.S. researcher suggests there is a genetic link between Parkinson's disease and manganese poisoning. The study, published in Nature Genetics, ties Parkinson's disease to a protein in the brain -- alpha synuclien -- misfolding and forming clumps on the basis of how the protein behaves in the type of yeast used in baking and brewing. The similarity was discovered by Aaron Gitler -- studying yeast while at England's Whitehead Institute in Cambridge -- after reading about a type of Parkinson's...

2009-01-02 09:14:42

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells? One possible answer: by breaking a survival circuit called MEF2D. Researchers at Emory University School of Medicine have...

2008-12-11 06:02:00

VIENNA, Austria, December 11 /PRNewswire/ -- AFFiRiS has started pre-clinical development of a Parkinson's vaccine. The vaccine, known as PD01, can be used to target a specific protein that is closely associated with the causes of this degenerative neurological disease. Excellent product candidates from discovery studies have prompted the company to file a patent application and proceed immediately with development. Similarly positive results from external assessments impelled the...

2008-11-04 15:00:05

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that it has published new research with collaborators at Mayo Clinic in the journal Molecular Neurodegeneration. The new pre-clinical findings demonstrate durable therapeutic silencing of the alpha-synuclein gene when small interfering RNAs (siRNAs), the molecules that mediate RNAi, are administered by direct delivery to the CNS in mice. Alpha-synuclein is believed to play a central role in the...

2007-08-23 03:19:55

By Mrak, Robert E Griffin, W Sue T Abstract Cortical Lewy body disease as a cause of dementia has been recognized for more than 40 years. Only in the past 15 to 20 years, however, has the true frequency of this entity come to be appreciated, primarily because of the advent of sensitive and specific immunohistochemical diagnostic techniques. We now know that there is frequent and extensive overlap, both clinically and pathologically, between Lewy body and Alzheimer diseases. Although some of...

2005-11-16 14:51:38

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a series of transgenic mouse models of multiple system atrophy, a progressive, fatal neurological disorder. The work is reported in the November 16 issue of the Journal of Neuroscience by Eliezer Masliah, M.D., Professor of Neuroscience and Pathology at UCSD and Cliff Shults, M.D. Professor of Neuroscience at UCSD and Neurologist at the VA San Diego Healthcare System. The mouse models are...

2005-11-03 14:18:53

DALLAS - Nov. 3, 2005 - Researchers at UT Southwestern Medical Center have discovered that a protein associated with causing neurodegenerative conditions may, when appearing in normal amounts, actually protect against neurodegeneration. The findings, appearing in today's issue of the journal Cell, have surprised the researchers, because an excess of the same specific protein - alpha-synuclein - causes Parkinson's disease. "It's the first time that anyone has shown that synuclein has any...

2005-06-21 19:05:00

DALLAS - June 21, 2005 - Researchers at UT Southwestern Medical Center have discovered a mechanism that causes a protein to clump together in brain cells of people with Parkinson's disease, pointing toward a possible treatment for the condition. The protein clumping is part of a "vicious cycle," the researchers said. As the proteins cluster, they inhibit an enzyme that normally breaks them down, leading to the formation of even more masses. "It's a disease involving accumulation of a protein...


Word of the Day
barghest
  • A goblin in English folklore, often appearing in the shape of a large dog and believed to portend imminent death or misfortune.
  • A ghost, wraith, hobgoblin, elf, or spirit.
The origin of 'barghest' is not known, but it may be from perhaps burh-ghest, town-ghost, or German Berg-geist (mountain spirit) or Bär-geist (bear-spirit).
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