Latest Alternative splicing Stories
University of Georgia scientists looking to understand the genetic mechanisms of plant defense and growth have found for the first time in plants an inverse relationship between gene duplication and alternative splicing.
Emotions, popularly seated in the heart, shift with the alternative stimuli of love, hate and emotion.
The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing.
Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs.
PARIS, March 16 /PRNewswire-FirstCall/ -- ExonHit Therapeutics (Alternext: ALEHT) today reported the publication in Lancet Oncology of a study conducted by Institut Gustave Roussy, which describes the identification of a deregulated cell function in breast cancer through the analysis of alternative RNA splicing .
Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia (PCH).
An international research team led by Tim Nilsen, Ph.D., a professor of medicine and biochemistry and the director of the School of Medicine's Center for RNA Molecular Biology, has discovered an unexpected mechanism governing alternative splicing, the process by which single genes produce different proteins in different situations. The new mechanism suggests that curing the more than half of genetic diseases that are caused by mutations in the genetic code that in turn create mistakes in...
By Courts, Cornelius Montesinos-Rongen, Manuel; Brunn, Anna; Bug, Stefanie; Siemer, Dorte; Hans, Volkmar; Blumcke, Ingmar; Klapper, Wolfram; Schaller, Carlo; Wiestler, Otmar D; Kuppers, Ralf; Siebert, Reiner; Deckert, Martina Abstract Primary lymphomas of the CNS (PCNSLs) show molecular features of the late germinal center exit B-cell phenotype and are impaired in their terminal differentiation as indicated by a lack of immunoglobulin class switching.
By Ponomarev, Vladimir Recent years have witnessed a remarkable increase in our knowledge and understanding of the genetics and molecular biology of human diseases. During the past 2 decades, technologic innovations revolutionized molecular and cell biology.
Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns).
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