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Latest AMP-activated protein kinase Stories

2014-03-06 08:30:40

Initiates Phase 1 Trial for Intermittent Claudication SOUTH SAN FRANCISCO, Calif., March 6, 2014 /PRNewswire/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that the American Journal of Physiology has published recent research results with its orally-bioavailable AMPK activator, R118. The publication, entitled "Exercise performance and peripheral vascular insufficiency improve with AMPK activation...", provides strong preclinical evidence that R118 may be useful in...

2014-01-13 16:25:24

CINCINNATI, Jan. 13, 2014 /PRNewswire-USNewswire/ -- The diabetes drug metformin is also being tested in numerous clinical trials for treating different cancers, and several studies point to its apparent activation of a molecular regulator of cell metabolism called AMPK to suppress tumor growth. (Logo: http://photos.prnewswire.com/prnh/20110406/MM79025LOGO) But new research appearing the week of Jan. 13 in Proceedings of the National Academy of Sciences (PNAS) suggests that...

2013-11-04 14:18:31

Metformin may reduce food intake and body weight, but the anorexigenic effects of metformin are still poorly understood. Under normal physiological conditions, Prof. Zheng Zhao and his team from the Key Laboratory of Brain Functional Genomics, Ministry of Education, China observed the changes in food intake after administration of metformin. They found that the central administration of metformin significantly reduced food intake and body weight gain, and a reduction of neuropeptide Y...

Revealing The Secrets Of How Diabetes Drug Metformin Works
2013-11-04 07:28:51

redOrbit Staff & Wire Reports - Your Universe Online Researchers from McMaster University in Hamilton, Ontario have discovered how metformin, one of the world’s most commonly prescribed diabetes drugs, interacts with insulin in order to lower a person’s blood sugar. According to the study authors, approximately 120 million people, globally, with Type 2 diabetes use the medication to control their disease, including two million in Canada. While doctors had known that metformin...

2013-10-03 09:06:40

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered some key features that explain just what turns on a protein that is considered to be a master regulator of how the human body uses and stores energy. The new discoveries could help in the design and development of new therapeutics to treat metabolic disease such as diabetes and obesity—and perhaps some cancers as well. The new study, led by Patrick R. Griffin, chair of the TSRI Department of...

Diabetes Drug Metformin Works Differently Than Previously Believed
2013-01-07 04:40:00

redOrbit Staff & Wire Reports - Your Universe Online Metformin, the drug most frequently prescribed by doctors to treat Type 2 Diabetes, works differently than previously believed -- a discovery which could lead to new treatments that have fewer side effects. Lead researcher Dr. Morris J. Birnbaum, a professor at the University of Pennsylvania's Institute for Diabetes, Obesity, and Metabolism (IDOM), and an international team of scientists have discovered that, in mice, metformin...

2012-07-16 23:03:54

A recent study by researchers at the Beth Israel Deaconess Medical Center (BIDMC), published in the July 3 issue of Cell Metabolism, has identified the link between metabolic disease and cancer. Senior author Barbara Kahn, MD, a scientist at BIDMC and Professor of Medicine at Harvard Medical School, stated that “Maintaining normal body weight requires tight control of energy homeostasis, which necessitates a constant flow of metabolic input to the hypothalamus in the form of nutrients...

2012-07-06 11:40:42

New research in the FASEB Journal suggests that the protein AMPK plays a role in protecting sensory cells in the inner ear from permanent damage and helps maintain hearing after extreme noise exposure If you're concerned about losing your hearing because of noise exposure (earbud deafness syndrome), a new discovery published online in the FASEB Journal offers some hope. That's because scientists from Germany and Canada show that the protein, AMPK, which protects cells during a lack of...

2012-05-01 21:19:57

New research reinforces the claim that resveratrol–a compound found in plants and food groups, notably red wine–prolongs lifespan and health-span by boosting the activity of mitochondria, the cell's energy supplier. "The results were surprisingly clear," said David Sinclair, a professor of genetics at Harvard Medical School and the study's senior author. "Without the mitochondria-boosting gene SIRT1, resveratrol does not work." Over the last decade, Sinclair and colleagues...

Aspirin Ingredient Triggers Possible Cancer, Diabetes-Fighting Protein
2012-04-21 05:25:56

An international team of scientists has discovered a link between the active ingredient in aspirin and a protein which helps regulate cell growth and metabolism -- a link which could mean that the same anti-inflammatory medication and pain reliever might potentially be able to help treat cancer and prevent Type 2 Diabetes. Those researchers, who hail from at McMaster University in Canada; the University of Dundee in Scotland, and the University of Melbourne in Australia, have discovered...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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