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Latest AMPA receptor Stories

2014-06-25 10:21:35

Cold Spring Harbor Laboratory There are new clues about malfunctions in brain cells that contribute to intellectual disability and possibly other developmental brain disorders. Professor Linda Van Aelst of Cold Spring Harbor Laboratory (CSHL) has been scrutinizing how the normal version of a protein called OPHN1 helps enable excitatory nerve transmission in the brain, particularly at nerve-cell docking ports containing AMPA receptors (AMPARs). Her team's new work, published June 24 in...

2011-12-14 10:18:39

An inhibitory drug reverses seizure damage to neurologic pathways in rats About half of newborns who have seizures go on to have long-term intellectual and memory deficits and cognitive disorders such as autism, but why this occurs has been unknown. In the December 14 Journal of Neuroscience, researchers at Children's Hospital Boston detail how early-life seizures disrupt normal brain development, and show in a rat model that it might be possible to reverse this pathology by giving certain...

2011-10-19 20:20:33

OPHN1 is found to be essential for mGluR-dependent long-term depression at synapses Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses — the tiny gaps across which nerve cells in the brain communicate — and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders. A team led by CSHL Professor Linda Van Aelst...

2011-10-11 17:55:39

A tiny piece of a critical receptor that fuels the brain and without which sentient beings cannot live has been discovered by University at Buffalo scientists as a promising new drug target for Alzheimer's and other neurodegenerative diseases. The research on the NMDA (N-methyl-D-aspartate) receptor is being published online Oct. 11 in Nature Communications. "This is the first time that this site has been shown to be useful as a drug target," says Gabriela K. Popescu, PhD, associate...

2011-09-28 10:35:45

Researchers working with adult mice have discovered that learning and memory were profoundly affected when they altered the amounts of a certain protein in specific parts of the mammals' brains. The protein, called kibra, was linked in previous studies in humans to memory and protection against late-onset Alzheimer's disease. The new work in mice, reported in the Sept. 22 issue of Neuron, shows that kibra is an essential part of a complex of proteins that control the sculpting of brain...

2010-10-08 02:27:38

New method helps explain synapse formation By creating a better way to see molecules at work in living brain cells, researchers affiliated with MIT's Picower Institute for Learning and Memory and the MIT Department of Chemistry are helping elucidate molecular mechanisms of synapse formation. These studies could also help further understanding of how synapses go awry in developmental diseases such as autism and Fragile X syndrome. The study will appear in the Oct. 7 issue of Cell. Using the...

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2010-04-20 13:14:48

Researchers at the University of Illinois have identified a potential drug target for the treatment of Alzheimer's disease: a receptor that is embedded in the membrane of neurons and other cells. A protein fragment associated with Alzheimer's disease activates this receptor, sparking increased activity in the affected neurons, eventually leading to cell death, the researchers report. The new findings appear in the FASEB Journal. Scientists have known for decades that a protein fragment,...

2006-03-30 03:25:00

John's Hopkins researchers have shown that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are important for allowing certain nerve cells to learn. These nerve cells, called Purkinje cells, become desensitized in response to signals from neighboring cells in a process known as long-term depression (LTD.). It is this process that allows them to learn certain motor skills such as the vestibulo-ocular reflex which coordinates eye movements with head...


Word of the Day
baudekin
  • A rich embroidered or brocaded silk fabric woven originally with a warp of gold thread.
'Baudekin' seems to be an alternative form of 'baldachin,' from the Italian 'Baldacco,' Baghdad, the city where the material was made.
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