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Latest amphotericin B Stories

2014-04-16 12:13:16

Scientists have solved a decades-old medical mystery – and in the process have found a potentially less toxic way to fight invasive fungal infections, which kill about 1.5 million people a year. The researchers say they now understand the mechanism of action of amphotericin, an antifungal drug that has been in use for more than 50 years – even though it is nearly as toxic to human cells as it is to the microbes it attacks. A report of the new findings appears in Nature Chemical...

2014-03-11 16:26:16

Company launches anti-fungal AmBisome® as one of the segment's first product offerings MUMBAI, India and PITTSBURGH, March 11, 2014 /PRNewswire/ -- Mylan Inc. (Nasdaq: MYL), one of the world's leading generic and specialty pharmaceutical companies, today announced that its subsidiary, Mylan Pharmaceuticals Private Limited, has launched a Critical Care segment in India. The new segment focuses on anti-fungal, antibiotics and anti-coagulant therapies. AmBisome(®), a leading...

2013-11-21 13:08:56

First line anti-viral protein rendered ineffective by Amphotericin B Scientists at the University of Massachusetts Medical School (UMMS) and the Wellcome Trust Sanger Institute have discovered evidence that a widely used anti-fungal medicine increases susceptibility to flu infection in mice and cell cultures. Published online in Cell Reports, the study shows that Amphotericin B, commonly given to cancer and bone marrow transplant patients to fight invasive fungal infections, neutralizes an...

2013-11-21 12:42:27

Mice given a drug commonly used in patients to fight systemic fungal infections more often succumb to what would otherwise be a mild case of the flu. The evidence reported in the Cell Press journal Cell Reports on November 21st shows that the drug called Amphotericin B, which has an estimated $330 million in sales around the world each year, can render a protein important for antiviral defense ineffective in both cells and mice. The findings suggest that patients receiving the antifungal...

2013-11-05 10:26:49

An 83 percent improvement in efficacy in the drug most commonly used to treat leishmaniasis The Amphotericin B (AmB) is the main active ingredient in the most effective drug used to treat leishmaniasis, a disease which in the Western world mainly affects dogs, but in developing countries affects over 12 million people, with more than 70,000 deaths per year. The cost of treating humans with AmB surpasses $5,000 per patient, the treatment is extensive (2-hour sessions every day during 21...

2013-09-09 20:33:58

The vision for a new branch of medicine, inspired by the ancient field that began with peg legs and hand hooks, commanded the spotlight in a major address by its pioneer here today at the 246th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society. Martin D. Burke, M.D., Ph.D., focused on the field he has named "molecular prosthetics," after the small molecules that make up the ingredients in most drugs and the branch of medicine...

2012-10-29 12:01:15

Analysis will help development of new treatments to protect vulnerable patients undergoing chemotherapy or suffering from HIV Neutron scattering experiments have provided new insights into the origin of the side effects of an antifungal drug prescribed all over the world. The analysis conducted by scientists at King's College London and the Institut Laue-Langevin in Grenoble, and published in Scientific Reports, follows 40 years of debate and could help drug developers reduce these harmful...

2012-09-26 13:23:07

The most cost-effective treatment for cryptococcal meningitis (a serious infection of the brain membranes, usually in people with AIDS or other immune system deficiencies) is different to that currently recommended by the World Health Organization (WHO), warranting a review of policy, according to the findings of a study published in this week's PLOS Medicine. Researchers from Makerere University in Kampala, Uganda, and from the University of Minnesota in the US found that a short (7-day)...

2012-01-16 21:13:31

With one simple experiment, University of Illinois chemists have debunked a widely held misconception about an often-prescribed drug. Led by chemistry professor and Howard Hughes Medical Institute early career scientist Martin Burke, the researchers demonstrated that the top drug for treating systemic fungal infections works by simply binding to a lipid molecule essential to yeast's physiology, a finding that could change the direction of drug development endeavors and could lead to better...


Word of the Day
reremouse
  • A bat.
The word 'reremouse' comes from Middle English reremous, from Old English hrēremūs, hrērmūs ("bat"), equivalent to rear (“to move, shake, stir”) +‎ mouse.
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