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Last updated on April 18, 2014 at 5:21 EDT

Latest Amyloid precursor protein Stories

2014-04-16 11:43:12

UC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models. Alzheimer's disease, one of the most common forms of dementia, is associated with accumulation of the protein amyloid-beta in the brain in...

2014-04-14 14:20:45

Alzheimer's disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden of the disease in 2050 is estimated to be a half a trillion US dollars, a figure equivalent to the government's annual revenues. Unfortunately, it has proven very difficult to develop drugs capable of ameliorating the disease. After a tremendous burst of progress in the 1990s, the pace of discoveries has slowed. Dr. Saido believes that...

2014-02-20 08:31:52

- Milestone achieved for BI's initiation of Phase 1 study in beta-secretase (BACE) inhibitor program FORT WASHINGTON, Pa., Feb. 20, 2014 /PRNewswire/ -- Vitae Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on discovering and advancing novel, small molecule, best-in-class compounds, announced today that it has earned a $14 million milestone payment from Boehringer Ingelheim (BI) for BI's initiation of a Phase 1 clinical trial in the companies' beta-secretase...

Unraveling Mysteries Of Amyloid Beta Peptides To Detect And Treat Alzheimer's Disease
2014-02-18 07:41:38

American Institute of Physics Alzheimer's disease has long been marked by progress -- but not the kind of progress the medical community seeks. It is the most common form of dementia among older Americans, and its risk increases with increasing age; for those living with the disease, its ravages get worse over time; and as we move into the 21st century, it will place a greater and greater burden on society. The number of Americans living with Alzheimer's has doubled since 1980 and is...

2014-01-20 12:26:21

Study uncovers role of Neuroligin-1 protein Cleveland Clinic researchers have identified a protein in the brain that plays a critical role in the memory loss seen in Alzheimer's patients, according to a study to be published in the journal Nature Neuroscience and posted online today. The protein – Neuroligin-1 (NLGN1) – is known to be involved in memory formation; this is the first time it's been linked to amyloid-associated memory loss. In Alzheimer's disease, amyloid beta...

2014-01-13 10:21:10

New Study Pinpoints Structural Effects of V44M and V44A Mutations New research, led by Rensselaer Polytechnic Institute researcher Chunyu Wang, has solved one mystery in the development of Familial Alzheimer’s Disease (FAD), a genetic variant of the disease that affects a small fraction of the Alzheimer’s population. In a paper published January 6 in the journal Nature Communications, Wang and his team follow the trail of two genetic mutations – V44M and V44A – known to cause FAD,...

Alzheimer’s Disease Tracked From The Beginning
2013-12-23 04:42:10

redOrbit Staff & Wire Reports - Your Universe Online By combining high-resolution functional MRI (fMRI) imaging scans in Alzheimer’s disease patients with mouse models of the neurodegenerative condition, researchers from Columbia University Medical Center (CUMC) have gained new insights into how, where and why the disease starts and spreads. The study, which was published Sunday in the online edition of Nature Neuroscience, will help enhance the medical community’s understanding...

2013-12-16 18:13:17

Massive neuron death that occurs in Alzheimer's appears to be caused by raw ingredients of plaques & tangles working in concert, rather than by plaques and tangles themselves Much of the debate in Alzheimer's disease (AD) has focused on whether the protein amyloid-beta or the tau protein is the symptom or the cause of the disease. But George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued another hypothesis: much earlier interactions between the two...

Study Suggests Brain Blood Vessel Cells May Be Therapeutic Targets For Alzheimer's Disease
2013-12-13 14:28:51

NIH/National Institute of Neurological Disorders and Stroke A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses. "This study helps show how the brain's vascular system may contribute to the development of Alzheimer's disease," said study leader Berislav V....

2013-11-12 08:34:45

Data Presented at Society for Neuroscience 2013 Annual Meeting NEW YORK, Nov. 12, 2013 /PRNewswire/ -- Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB: AVXL) is pleased to announce that new study data showed ANAVEX 2-73 to be effective in counteracting the progression of Alzheimer's disease under chronic treatment in a transgenic mouse model of Alzheimer's, named Tg2576. The new data was presented by Tangui Maurice, PhD, CNRS Research Director at the University of...