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Latest Amyloid precursor protein Stories

2012-03-01 11:02:05

Neuroscientists show that HDAC2 enzyme could be a good target for new drugs MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms. The finding suggests that drugs targeting the enzyme, known as HDAC2, could be a promising new approach to treating the disease, which...

2012-03-01 01:56:53

In a mouse model of Alzheimer's disease, memory problems stem from an overactive enzyme that shuts off genes related to neuron communication, a new study says. When researchers genetically blocked the enzyme, called HDAC2, they 'reawakened' some of the neurons and restored the animals' cognitive function. The results suggest that drugs that inhibit this particular enzyme would make good treatments for some of the most devastating effects of the incurable neurodegenerative disease. "It's...

2012-03-01 01:55:51

NIH-funded research could lead to new therapy A repression of gene activity in the brain appears to be an early event affecting people with Alzheimer's disease, researchers funded by the National Institutes of Health have found. In mouse models of Alzheimer's disease, this epigenetic blockade and its effects on memory were treatable. "These findings provide a glimpse of the brain shutting down the ability to form new memories gene by gene in Alzheimer's disease, and offer hope that we...

2012-02-15 06:41:44

(Ivanhoe Newswire) -- From stress to insomnia to anxiety, whatever the cause may be, new research shows that lack of sleep at night could affect memory later in life. “Disrupted sleep appears to be associated with the build-up of amyloid plaques, a hallmark marker of Alzheimer´s disease, in the brains of people without memory problems. Further research is needed to determine why this is happening and whether sleep changes may predict cognitive decline,” the study author at...

2012-02-10 15:06:20

“In the last eight days, scientists have delivered a powerful one-two punch in the fight to defeat Alzheimer´s disease,” said Stacy Pagos Haller, President and CEO of the American Health Assistance Foundation (AHAF), a nonprofit that identifies and funds exceptionally high-impact research worldwide through its  Alzheimer´s Disease Research program. “We are excited about today´s announcement by Case Western University researchers that a cancer drug,...

Alzheimer’s Breakthrough: Drug Appeared To Reverse Symptoms In Mouse Trial
2012-02-10 10:23:41

Scientists, long searching for a cure for Alzheimer´s, a reporting a dramatic breakthrough: a drug that quickly reverses the pathological, cognitive and memory deficits in mice afflicted with the disease. The results point to the significant potential that the drug, bexarotene, could help the more than 5 million Americans suffering from the brain disease. However, they cautioned that the study was only used in mice, and that the research needs much more work to determine if the...

2012-01-27 14:17:49

Stowers researchers discovered that a prion-like protein plays a key role in storing long-term memories Memories in our brains are maintained by connections between neurons called "synapses". But how do these synapses stay strong and keep memories alive for decades? Neuroscientists at the Stowers Institute for Medical Research have discovered a major clue from a study in fruit flies: Hardy, self-copying clusters or oligomers of a synapse protein are an essential ingredient for the...

Brain Boosting Activities Early In Life May Cut Later Risk Of Alzheimer’s
2012-01-25 06:32:24

A new study suggests that people who engage in mentally stimulating activities such as reading and playing games — particularly early in life -- may be lowering levels of a brain protein linked to Alzheimer's disease. The protein, known as beta-amyloid protein, is the main component of the destructive brain-clogging plaques that are a hallmark of Alzheimer´s disease. Researchers at the University of California Berkeley surveyed 65 healthy elderly people, whose average age was...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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