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Latest Amyloid precursor protein Stories

2011-01-26 20:29:20

Misaligned research, medical challenges and harsh economics are thwarting efforts to slow the destructive course of Alzheimer's disease in the United States, according to a trio of nationally regarded Alzheimer's researchers writing a "Perspective" in Thursday's (Jan. 27) issue of the journal Neuron. The foremost obstacle is that the most promising preventive strategies are being tested in patients firmly in the grip of Alzheimer's disease "” the ones least likely to be helped. The...

2011-01-18 23:14:37

Older adults without dementia and with lower levels in plasma of the biomarkers beta-amyloid 42/40 (protein fragments) had an increased rate of cognitive decline over a period of 9 years, according to a study in the January 19 issue of JAMA. The researchers also found that this relationship was stronger among individuals with less education and lower levels of literacy. An estimated 36 million people currently have dementia, with the prevalence expected to double every 20 years, according to...

2011-01-12 15:49:34

Study in mice indicates disease's underlying causes and finds compounds that normalize the Alzheimer's brain A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States. The BRNI study is the first to achieve fundamental...

2011-01-11 16:01:00

Study in Mice Indicates Disease's Underlying Causes and Finds Compounds That Normalize the Alzheimer's Brain MORGANTOWN, W.Va., Jan. 11, 2011 /PRNewswire-USNewswire/ -- A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United...

2010-12-07 07:29:05

(Ivanhoe Newswire) -- We're all familiar with the term biological clock.  Some of us are perhaps familiar with the sound it makes when it starts to tick.  What we may not be familiar with, however, is that the season in which babies are born can have a remarkable and unrelenting effect on how the gears of their biological clocks function. The conclusion of a recent experiment provides the foremost evidence for seasonal imprinting of biological clocks in mammals.  The imprinting...

2010-12-02 23:45:40

Study Highlights:     * A blood vessel dysfunction linked to cardiovascular disease seems to also play a role in Alzheimer's disease.    * The dysfunction may help account for the buildup of amyloid plaques in the brains of Alzheimer's patients. A dysfunction in the lining of blood vessels that is linked to cardiovascular illness also appears to play a role in the development of Alzheimer's disease, according to a study published in Circulation Research: Journal...

2010-11-18 14:40:30

Asthma inhibitors could help control or treat the disease A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine. The researchers also found that inhibitors of this protein currently used to control asthma could possibly be...

2010-11-17 14:05:19

Specific brain changes suggest new diagnostic markers and therapeutic targets New studies identify brain changes in people with Alzheimer's disease. The results give researchers a greater understanding of the disease and may help at-risk individuals by improving early detection. New animal research also shows a novel approach to Alzheimer's vaccine design that may avoid dangerous side effects. These new results were reported at Neuroscience 2010, the annual meeting of the Society for...

2010-11-15 16:13:46

Alzheimer's disease is widely believed to be caused by the gradual accumulation in the brain of amyloid-beta peptide which is toxic to nerve cells. Amyloid beta peptide is formed from a protein known as APP, which is found in three forms. Most research into APP "“ a key area of study for the disease "“ does not distinguish between the different forms of the protein. The findings, published in the Journal of Biological Chemistry, show that amyloid beta peptide is actually created...

2010-11-04 08:25:26

(Ivanhoe Newswire) -- Scientists at the Gladstone Institute of Neurological Disease (GIND) have offered new information about the events that underlie the "spread" of Alzheimer's disease (AD) throughout the brain. The research follows disease progression from a vulnerable brain region that is affected early in the disease to interconnected brain regions that are affected in later stages. The findings may contribute to design of therapeutic interventions, as targeting the brain region where AD...