Quantcast

Latest Amyloid precursor protein Stories

2010-11-04 01:29:11

Scientists at the Gladstone Institute of Neurological Disease (GIND) have offered new information about the events that underlie the "spread" of Alzheimer's disease throughout the brain. The research, published in the November 4th issue of the journal Neuron, follows disease progression from a vulnerable brain region that is affected early in the disease to interconnected brain regions that are affected in later stages. The findings may contribute to design of therapeutic interventions, as...

2010-10-12 18:38:00

Mount Sinai School of Medicine researchers have found that a gene associated with the onset of Type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer's disease. The research, led by Giulio Maria Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry and Geriatrics and Adult Development at Mount Sinai School of Medicine, was published this month in Aging Cell. The new study provides insight into a potential mechanism that might...

2010-10-06 23:09:17

Scientists say results fill in gaps of story, lay foundation for therapies to prevent or stall plaques Massachusetts General Hospital researchers say they have determined how iron contributes to the production of brain-destroying plaques found in Alzheimer's patients. The team, whose study results appear in this week's Journal of Biological Chemistry, report that there is a very close link between elevated levels of iron in the brain and the enhanced production of the amyloid precursor...

2010-09-29 13:05:32

As researchers try to understand how a particular protein sets the stage for the toxic plaques that wreak havoc on the brains of people with Alzheimer's disease, they face a dilemma. This protein, called the amyloid precursor protein, not only begins the damaging process that results in Alzheimer's, it also has a critical biological function in brain development and in the synapse (the junction between nerve cells or nerve and muscle cells). To figure out how this protein causes Alzheimer's,...

2010-09-27 10:55:00

SARASOTA, Fla., Sept. 27 /PRNewswire-USNewswire/ -- Scientists at the Roskamp Institute in Sarasota, Florida, have shown that mice that naturally develop Alzheimer's are able to ward off the growth of brain cancer. In a series of experiments published in the Journal of Neuroscience, they showed that mice that spontaneously develop Alzheimer's Disease are able to dramatically reduce the growth of a human brain cancer. Brain cancers affect 612,000 people in the United States and are...

2010-09-21 22:06:50

Neurological researchers at Rush University Medical Center have found a new therapeutic target that can potentially lead to a new way to prevent the progression of Alzheimer's disease. The target called neutral sphingomyelinase (N-SMase) is a protein that when activated, can cause a chain of reactions in the cell leading to neuronal death and memory loss. Results from the study funded by the National Institutes of Health and the Alzheimer's Association will be published in the September 22...

7a6817b146698cc335c87ba637d4d31d1
2010-09-17 15:09:03

By Jim Dryden, Washington University in St. Louis An international team of Alzheimer's disease experts, led by Washington University School of Medicine in St. Louis, has uncovered a gene variation that appears to predict the rate at which Alzheimer's disease will progress. The investigators report their findings online in the journal Public Library of Science (PLoS) Genetics. Whereas previous studies have focused on factors that influence the risk for Alzheimer's, the new research points to a...

2010-09-16 17:07:05

Elevated levels of a growth protein in the brains of Alzheimer's disease (AD) patients is linked to impaired neurogenesis, the process by which new neurons are generated, say researchers at the University of California, San Diego in today's edition of The Journal of Neuroscience. Eliezer Masliah, MD, professor of neurosciences and pathology in the UC San Diego School of Medicine and colleagues report that increased levels of BMP6 "“ part of a family of bone morphogenetic proteins...

2010-09-11 02:16:25

In people with Alzheimer's, the brain becomes riddled with clumps of protein, forming what are known as amyloid plaques. Now, a report appearing in the September 17th print issue of Cell appears to have found a function for the amyloid precursor protein (APP for short) that yields the prime ingredient in those plaques. It turns out that APP is an iron oxidase whose job it is to convert iron from an unsafe form to a safe one for transport or storage. When APP fails to function properly, as it...

2010-09-09 01:09:20

Data published in Neuron demonstrate proof of concept in long term prevention of disease pathology in a mouse model, without GI side effects In the Sept 9, 2010 issue of Neuron, Neurogenetic Pharmaceuticals, Inc. (NGP) reports proof of concept studies that show its proprietary compound, NGP 555, is effective in preventing the amyloid pathology of Alzheimer's disease (AD) in a transgenic mouse model. The study further demonstrates that following chronic treatment with the gamma secretase...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.