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Latest Amyloid precursor protein Stories

2010-06-25 16:20:57

Scientists discovered characteristic amyloid plaques in retinas from Alzheimer's disease patients and used a noninvasive optical imaging technique to detect retinal plaques in live laboratory mice, suggesting the possibility of early noninvasive diagnosis The nerve cell-damaging plaque that builds up in the brain with Alzheimer's disease also builds up in the retinas of the eyes "“ and it shows up there earlier, leading to the prospect that noninvasive optical imaging of the eyes could...

2010-06-25 16:15:36

New tool could aid in diagnosing Alzheimer's, tracking disease progression and developing therapeutics A trial of a novel radioactive compound readily and safely distinguished the brains of Alzheimer's disease patients from healthy volunteers on brain scans and opens the doors to making such imaging available beyond facilities that can manufacture their own radioactive compounds. The results, reported by a Johns Hopkins team in the June Journal of Nuclear Medicine, could lead to better ways...

2010-06-18 12:58:12

The first trial of a new model for testing Alzheimer's treatments has reassured researchers that a promising class of drugs does not exacerbate the disease if treatment is interrupted. Scientists at Washington University School of Medicine in St. Louis and Merck & Co. Inc studied the effects of a class of drugs known as gamma secretase inhibitors. Researchers had worried that these drugs might cause a build-up of proteins linked to Alzheimer's disease and that this build-up could be...

2010-06-11 01:45:50

Findings could pave the way for novel treatments Researchers have discovered how mutations in the presenilin 1 gene cause early-onset Alzheimer's disease (AD). The finding, reported online in the journal Cell, opens the door to developing novel treatments for this form of the mind-robbing disease and for the more common, late-onset form that develops later in life and affects millions of people worldwide. The presenilin gene is most commonly associated with the early-onset familial form of...

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2010-04-20 13:14:48

Researchers at the University of Illinois have identified a potential drug target for the treatment of Alzheimer's disease: a receptor that is embedded in the membrane of neurons and other cells. A protein fragment associated with Alzheimer's disease activates this receptor, sparking increased activity in the affected neurons, eventually leading to cell death, the researchers report. The new findings appear in the FASEB Journal. Scientists have known for decades that a protein fragment,...

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2010-04-05 09:40:27

The neurodegenerative disease spinocerebellar ataxia type 5 (SCA5) damages nerve cells in two ways. University of Minnesota researchers now report that the defective protein responsible for the disease cuts the number of synaptic terminals and snarls traffic inside neurons. The study appears in the April 5 issue of the Journal of Cell Biology. SCA5 results from a faulty gene for {beta}-III"“spectrin. The disease targets the cerebellum's Purkinje cells, which control coordination....

2010-03-29 15:24:03

Blocking activity of PI3 kinase signaling protein improves memory By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer's disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, which was previously thought to have a protective function against the disease....

2010-03-22 14:45:03

Microglia are the cells responsible for immune surveillance in the brain, and they initiate protective inflammatory reactions in response to tissue damage and infection. An international team under the leadership of LMU neuroscientist Professor Jochen Herms has now shown that these cells may actually make a significant contribution to the loss of neurons associated with Alzheimer's disease. About 1.2 million people are thought to suffer from this form of progressive dementia in Germany, and...

2010-03-08 23:01:00

WASHINGTON, March 9 /PRNewswire-USNewswire/ -- According to the Alzheimer's Association's® 2010 Alzheimer's Disease Facts and Figures, African-Americans are about two times more likely and Hispanics are about one and one-half times more likely than their white counterparts to have Alzheimer's and other dementias. Although whites make up the great majority of the more than five million people with Alzheimer's and other dementias, African-Americans and Hispanics are at...

2010-03-03 09:09:58

Understanding amyloid-beta's normal function could lead to preventive, therapeutic strategies Amyloid-beta protein "“ the primary constituent of the plaques found in the brains of Alzheimer's disease patients "“ may be part of the body's first-line system to defend against infection. In their report in the March 3 issue of the open-access journal PLoS One, a team led by Massachusetts General Hospital (MGH) researchers describe their evidence that amyloid-beta protein (A-beta) is...


Word of the Day
baudekin
  • A rich embroidered or brocaded silk fabric woven originally with a warp of gold thread.
'Baudekin' seems to be an alternative form of 'baldachin,' from the Italian 'Baldacco,' Baghdad, the city where the material was made.
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