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Latest Amyloid precursor protein Stories

2010-03-22 14:45:03

Microglia are the cells responsible for immune surveillance in the brain, and they initiate protective inflammatory reactions in response to tissue damage and infection. An international team under the leadership of LMU neuroscientist Professor Jochen Herms has now shown that these cells may actually make a significant contribution to the loss of neurons associated with Alzheimer's disease. About 1.2 million people are thought to suffer from this form of progressive dementia in Germany, and...

2010-03-08 23:01:00

WASHINGTON, March 9 /PRNewswire-USNewswire/ -- According to the Alzheimer's Association's® 2010 Alzheimer's Disease Facts and Figures, African-Americans are about two times more likely and Hispanics are about one and one-half times more likely than their white counterparts to have Alzheimer's and other dementias. Although whites make up the great majority of the more than five million people with Alzheimer's and other dementias, African-Americans and Hispanics are at...

2010-03-03 09:09:58

Understanding amyloid-beta's normal function could lead to preventive, therapeutic strategies Amyloid-beta protein "“ the primary constituent of the plaques found in the brains of Alzheimer's disease patients "“ may be part of the body's first-line system to defend against infection. In their report in the March 3 issue of the open-access journal PLoS One, a team led by Massachusetts General Hospital (MGH) researchers describe their evidence that amyloid-beta protein (A-beta) is...

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2010-03-02 09:30:20

New model for testing anti-Alzheimer's drugs: At a pier near you Alzheimer's disease affects an estimated 27 million people worldwide. It is the most common form of age-related dementia, possibly the most feared disease of old age. There is no cure, and the available drugs only help to relieve symptoms without slowing progression of the disease. One of the characteristic changes in the brains of Alzheimer's patients is the accumulation of plaques and tangles; currently, the best hope for...

2010-03-01 15:14:02

Uncovers new explanation for the spread of key protein within the brain LOWELL, Mass. "“ A team of researchers at UMass Lowell has found a new mechanism by which a key protein associated with Alzheimer's disease can spread within the human brain. The research, led by UMass Lowell biological sciences professor Garth Hall, gives new hope that the disease may someday be cured. It provides a new explanation of how the protein tau, a normal human protein that becomes toxic in Alzheimer's...

2010-02-25 07:05:00

WASHINGTON, Feb. 25 /PRNewswire/ -- Complementary approaches to Alzheimer's research were recognized as four scientists received the prestigious MetLife Foundation Awards for Medical Research in Alzheimer's Disease in Washington, D.C. during a scientific briefing and luncheon. Todd E. Golde, M.D., Ph.D., professor of neuroscience at the University of Florida and director of its Center for Translational Research in Neurodegenerative Diseases, and Edward H. Koo, M.D., professor of...

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2010-02-08 10:34:32

The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study by researchers at the University of British Columbia and Vancouver Coastal Health Research Institute. The findings, published in the current issue of the journal Current Alzheimer Research, could lower expectations about the benefits of medical marijuana in combating various cognitive diseases and help redirect future research to more promising therapeutics. Previous...

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2010-01-07 08:15:00

Florida Alzheimer's Disease Research Center study in mice indicates long-term exposure to cell phone signals may even boost normal memory The millions of people who spend hours every day on a cell phone may have a new excuse for yakking. A surprising new study in mice provides the first evidence that long-term exposure to electromagnetic waves associated with cell phone use may actually protect against, and even reverse, Alzheimer's disease. The study, led by University of South Florida...

2010-01-04 15:34:28

Inheritance of an extra copy of the gene- ÃŽ² -amyloid precursor protein, APP, in individuals with Down syndrome leads to the inevitable development of early onset Alzheimer's disease, known to be linked to the deposition of Amyloid ÃŽ² peptide or AÃŽ² in the brain. However, a new study published online by Proceedings of the National Academy of Sciences identifies ÃŽ²CTF, a small protein found in APP, as a novel factor for...

2009-12-28 16:43:06

The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta (AÃŽ²) plays an important role in early synaptic failure, but little has been understood about AÃŽ²'s effect on the plasticity of dendritic spines. These spines are short outgrowths of dendrites (extensions of neurons) that relay electrical impulses in the brain. A single neuron's dendrite...